Original Article
Clinical value of sequential organ failure assessment score in evaluating organ function in acute pancreatitis
Zheng Xi, Li Lei, Zhu Yin, Lyu Nonghua, He Wenhua
Published 2020-02-15
Cite as Chin J Dig, 2020, 40(2): 110-114. DOI: 10.3760/cma.j.issn.0254-1432.2020.02.009
Abstract
ObjectiveTo compare the clinical value of sequential organ failure assessment (SOFA) score and revised Marshall score in evaluating organ function in acute pancreatitis (AP).
MethodsFrom January 2013 to December 2017, at the Department of Gastroenterology of The First Affiliated Hospital of Nanchang University, the clinical data of 3 957 hospitalized AP patients were collected through the AP electronic database. AP was diagnosed and the severity of the disease was classified according to the revised Atlanta classification criteria. Organ function was evaluated by modified Marshall score and SOFA score. The correlation between SOFA score and mortality, pancreatic necrosis were analyzed. Chi-square test and Spearman correlation analysis were performed for statistical analysis.
ResultsThe incidences of circulatory failure and renal failure determined by the SOFA score were higher than those of the modified Marshall score (4.80%, 190/3 957 vs. 3.03%, 120/3 957; 10.11%, 400/3 957 vs. 6.44%, 255/3 957), and the differences were statistically significant (χ2=1 599.54 and 2 237.19, both P<0.01). Two score systems were consistent in determining the incidence of respiratory failure, which were 32.22% (1 275/3 957). The incidences of persistent circulatory failure (≥48 h) and persistent renal failure (≥48 h) determined by the SOFA score were higher than those of the modified Marshall score (1.64%, 65/3 957 vs. 0.76%, 30/3 957; 4.78%, 189/3 957 vs. 3.69%, 146/3 957), and the differences were statistically significant (χ2=1 458.37 and 2 398.01, both P<0.01). The incidence of persistent respiratory failure (≥48 h) was same determined by two score systems, which were 10.24% (405/3 957). The proportion of patients with severe AP determined by SOFA score was higher than that of the modified Marshall score (25.30%, 1 001/3 957 vs. 18.83%, 745/3 957), and the difference was statistically significant (χ2=718.216, P<0.01). The results of Spearman correlation analysis showed that SOFA total score was positively correlated with the overall mortality and the incidence of pancreatic necrosis (correlation coefficients r were 0.540 and 0.211, respectively), and the differences were statistically significant (both P<0.01).
ConclusionSOFA score can comprehensively evaluate organ function in AP and is an important approach in determining prognosis.
Key words:
Sequential organ failure assessment score; Acute pancreatitis; Revised Marshall score; Organ function
Contributor Information
Zheng Xi
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Li Lei
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Zhu Yin
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
Lyu Nonghua
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
He Wenhua
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China
