Therapeutic effects of hyperbaric oxygen at different time points in infants with cerebral palsy
ZHU Min, ZHANG Yue, TANG Jian, FU Da-ling, LI Hong-ying, ZHAO Xiao-ke, DU Sen-jie
Published 2013-02-28
Cite as Chin J Naut Med & Hyperbar Med, 2013,20(01): 39-42,62. DOI: 10.3760/cma.j.issn.1009-6906.2013.01.013
Abstract
Objective To observe the therapeutic effects of hyperbaric oxygen (HBO) at different time points in infants with cerebral palsy.Methods Sixty cases of cerebral palsy with an age of 3 months were randomly divided into 4 groups:group 1,2,3,4,each consisting of 15 cases.All the infants of the 4 groups were given routine rehabilitation treatment until they were 1 year old.The sick infants in group 1,2 and 3started HBO therapy at the following ages:3 to 4 months old,4 to 6 months old and over 6 months old respectively,with a treatment course of 8 weeks and a total of 40 sessions.The infants in groups 4 were not treated with HBO.Gross motor function was evaluated with Gross Motor Function Measure (GMFM).Intelligence was evaluated with Gesell Development Scale.Then,developmental quotient and total developmental quotient in gross motor,fine motor,adaptation,language and individual-social domains were calculated.Results At one year old,GMFM,developmental quotients in the above five domains and total developmental quotients of all the sick infants in the 4 groups improved significantly,when compared with those before treatment.Of all the patients in the 4 groups,the patients in groups 1 improved more significantly than those in group 2,3 and 4,with statistical significance (P < 0.05).The patients in groups B improved more significantly than those in group 3 and 4,also with statistical significance (P < 0.05).No statistical significance could be noted in therapeutic effects,when a comparison was made between group 3 and 4 (P >0.05).No serious adverse reactions could be noticed in the patients of the 4 groups during treatment.Conclusions Therapeutic time points of HBO therapy played an important role in the treatment of cerebral palsy in infants.The earlier the HBO therapy was implemented,the better the treatment.Optimal therapeutic effects could be achieved,if HBO therapy was started within 3 to 4 months after onset of the disease.Less optimal therapeutic results could be achieved,if HBO intervention was given within 4 to 6 months.And there would be no significant effects,if HBO therapy was started 6 months after the onset of disease.
Key words:
Cerebral palsy; Hyperbaric oxygen; Therapeutic time points; Therapeutic effects
Contributor Information
ZHU Min
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
ZHANG Yue
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
TANG Jian
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
FU Da-ling
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
LI Hong-ying
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
ZHAO Xiao-ke
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China
DU Sen-jie
Department of Rehabilitation, Nanjing Children 's Hospital Affiliated to Nanjing Medical University,Nanjing, 210008, China