To investigate the effects of hyperbaric oxygen (HBO) on serum intercellular adhesion molecule 1 (sICAM-1) and S100B proteins in the newborns with hypoxic ischemic encephalopathy (HIE).

Sixty-two HIE newborns admitted to the hospital from May 2016 to January 2019 were selected as research subjects. According to the random cluster method, they were divided into the observation group and the control group, each consisting of 31 patients. The control group was given routine treatment, while the observation group received HBO in addition to the treatment received by the control group. Ten days after treatment, the levels of NBNA, nerve reflex and consciousness recovery time, sICAM-1, S100B protein expression and adverse reactions were compared between the patients of the 2 groups.

Ten days after treatment, the NBNA scores of the 2 groups were all significantly higher than those before treatment. The NBNA scores of the observation group (30.18±5.04) was obviously higher than those of the control group (24.59±5.14), with statistical significance (P<0.05). Nerve reflex and consciousness recovery time of the observation group [(3.88±1.23), (2.45±0.94)d] were all significantly shorter than those of the control group [(5.69±1.37), (4.17±1.13)d], also with statistical significance (P<0.05). The expression levels of sICAM-1 and S100B in the patients of the 2 groups all decreased obviously as compared with those before treatment, and the levels of the observation group after treatment were evidently shorter than those of the control group, also with statistical significance (P<0.05). During the course of treatment, total rate of adverse reactions in the observation group was higher(12.9%)than that of the control group(9.7%), but without statistical significance (P>0.05).

HBO could improve the therapeutic effects on neonatal hypoxic ischemic encephalopathy and decrease the expression levels of SICAM-1 and S100B proteins.

Hyperbaric oxygen; Hypoxic ischemic encephalopathy; Intercellular adhesion molecule 1; S100B protein