Different Plasmodium species utilize specific set of ligand-receptor interactions accounting for the distinct invasive behavior of merozoites. Most studies on host cell invasion by Plosmodium are concentrated on red blood cell invasion. The members of proteins involved in erythrocyte-invasion processes, such as MSPs, EBL family, RBL family and motor protein have been identified with the help of classical studies and bioinformatic analysis. This review summarized the role of these proteins in the merozoite invasion processes.