Monoclonal antibodies have presented great efficacy in a variety of fields such as cancer and immune system disease therapy due to their strong targeting ability and few side effects. However, monoclonal antibodies targeting single specific site have limited clinical application. Therefore, bispecific antibodies binding two different epitopes on the same or different antigens could be potentially applied in tumor and autoimmune disease therapy. In recent years, more and more bispecific antibodies with different formats have entered clinical trials and achieved high efficacy. In this paper, the structure and clinical applications of various recombinant bispecific antibodies suitable for large-scale production at home and abroad are reviewed.

Bispecific antibodies; Structure; Clinical application