A case of extranodal NK/T-cell lymphoma, nasal type complicated by hemophagocytic syndrome
MA Han, SU Xiang-yang, LI Mei-rong, WAN Miao-jian, LAI Wei, LU Chun
Published 2011-03-15
Cite as Chin J Dermatol, 2011,44(03): 155-157. DOI: 10.3760/cma.j.issn.0412-4030.2011.03.002
Abstract
A 48-year-old man presented with a 4-day history of fever and 10-year history of papulovesicles on the face, neck, trunk and limbs which had been aggravated 10 days prior to the presentation.Skin biopsy showed a dermal infiltration of numerous small- to medium-sized atypical lymphocytes, which was mainly located around blood vessels or appendages, with the involvement of subcutaneous fat tissue and destruction of blood vessels. The infiltrating atypical cells stained positive for CD45RO, CD8, CD56, T-cell intracellular antigen-1, granzyme B, Epstein-Barr virus-encoded small nuclear RNAs (EBER), but negative for CD20, CD79a, CD3, CD4 or CD30. Cytoplasmic CD3ε was also observed in these cells. Laboratory examinations on admission revealed a progressive decrease in peripheral erythrocytes, white cells and platelets, persistent increase in serum aminotransferase and bilirubin, and decline in serum fibrinogen and hypertriglyceridemia. The B-mode ultrasound of the abdomen showed hepatosplenomegaly. Based on the above findings,the diagnosis was made as extranodal nasal type NK/T-cell lymphoma of skin complicated by hemophagocytic syndrome.
Key words:
Lymphoma, non-Hodgkin; Lymphohistiocytosis, hemophagocytic
Contributor Information
MA Han
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
SU Xiang-yang
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
LI Mei-rong
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
WAN Miao-jian
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
LAI Wei
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
LU Chun
Department of Dermatovenereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China