Research Report
Expression of interleukin-13 and its receptors in mycosis fungoides
Cheng Ding, Ping Wang, Jiao Liu, Zhao Li, Liuyu Li, Dongyin Liu, Junhui Zheng, Hong Shen
Published 2017-04-15
Cite as Chin J Dermatol, 2017, 50(4): 291-294. DOI: 10.3760/cma.j.issn.0412-4030.2017.04.013
Abstract
ObjectiveTo measure the expression of interleukin-13 (IL-13) and its receptors in mycosis fungoides (MF) lesions, and to investigate their clinical significance.
MethodsA total of 34 paraffin-embedded specimens of MF, which was confirmed by clinical and histopathological features, immunophenotyping and/or T-cell receptor gene rearrangements, were collected from Hangzhou Third People's Hospital between January 2010 and March 2016. According to the tumor-node-metastasis (TNM) staging system, 5 patients were at stageⅠA, 9 at stageⅠB, 17 at stageⅡA, and 3 at stageⅡB. Ten normal skin tissue specimens served as controls. Immunohistochemical study was conducted to measure the expression of IL-13, IL-13Rα1 and IL-13Rα2.
ResultsIL-13, IL-13Rα1 and IL-13Rα2 were all expressed in atypical lymphoid cells and epidermotropic lymphoid cells in MF lesions at various stages. IL-13Rα2 was highly expressed in all the MF lesions. None of IL-13 and its receptors were expressed in normal skin tissues and lymphocytes. The expression rates of IL-13 and its receptors in MF lesions increased along with the progression of MF. Additionally, the expression rates of IL-13 (10.00% ± 3.14%) , IL-13Rα1 (21.43% ± 6.88%) and IL-13Rα2 (31.14% ± 6.38%) significantly decreased in MF lesions at stage Ⅰ compared with those at stageⅡ (27.50% ± 11.00%, 39.45% ± 9.43%, 44.40% ± 11.15%, respectively, all P < 0.05) , but no significant differences were observed between stageⅠA andⅠB, or between stageⅡA and ⅡB (P > 0.05) .
ConclusionIL-13 and its receptors, especially IL-13Rα2, may be expected to serve as biomarkers for early diagnosis of MF and prediction of its biological behaviors.
Key words:
Mycosis fungoides; Cell transformation, neoplastic; Interleukin-13; Interleukin-13 receptor alpha1 subunit; Interleukin-13 receptor alpha2 subunit
Contributor Information
Cheng Ding
Department of Dermatology, Hangzhou Clinical College Affiliated to Anhui Medical University, Hangzhou 310009, China
Ping Wang
Department of Dermatology, Hangzhou Clinical College Affiliated to Anhui Medical University, Hangzhou 310009, China
Jiao Liu
Department of Dermatology, Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310009, China
Zhao Li
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China
Liuyu Li
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China
Dongyin Liu
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China
Junhui Zheng
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China
Hong Shen
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China