Objective To observe the effect of Narcotrend-guided target-controlled infusion of propofol in the double balloon enteroscopy in the elderly.Methods Forty ASA Ⅰ-Ⅱ,aged 65-75 patients undergoing double balloon enteroscopy (per anal) were randomized into two groups:target-controlled infusion of propofol guided by narcotrend level (NT group) or modified observer's assessment of alertness/sedation score (MOAA/S)(control group).In NT group,the target concentration of propofol was adjusted to achieve C2 level.In control group,the target concentration was adjusted achieve MOAA/S score of 2.Hemodynamic parameters,drug consumption,recovery time,adverse reactions,patient's and endoscopist's evaluation of satisfaction were recorded.Results Hemodynamic parameters are similar in both groups.In NT group,the consumption of propofol was less [(0.068±0.004) mg· kg-1· min-1vs (0.088±0.005) mg·kg-1·min-1,P＜0.05],recovery time was shorter [(13±4) min vs (18±5) min,P＜0.05] and the endoscopist's satisfaction was higher [(3.0±0.0) vs (2.8±0.4),P＜0.05].There is no significant difference in adverse reactions in both groups.Conclusions Narcotrend-guided anesthesia of propofol leads to less consumption of anesthetics,shorter recovery time and higher endoscopist satisfaction during double balloon enteroscopy in the elderly.