Original Article
Effect of dexmedetomidine on intestinal fatty acid binding protein in esophageal cancer patients receiving radical resection
Zhang Ying, Zhang Qi, Zhang Xiaofeng, Wang Aizhong, Xu Meiying
Published 2017-07-15
Cite as Int J Anesth Resus, 2017,38(07): 616-619. DOI: 10.3760/cma.j.issn.1673-4378.2017.07.010
Abstract
ObjectiveTo observe the effect of dexmedetomidine(Dex) on intestinal fatty acid binding protein(I-FABP) in esophageal cancer patients receiving radical resection.
MethodsForty patients undergoing esophageal cancer radical resection were randomly divided into two groups. In group D (n=20), 0.5 μg/kg Dex was intravenously infused within 10 min before anaesthesia, and was then persistently infused at the rate of 0.5 μg·kg-1·h-1. In group C(n=20), saline, instead of Dex, was infused with the same regimen as Dex. Blood samples were collected at a series of time points: 10 min before anaesthesia(T1), 10 min (T2), 1 h (T3), 2 h (T4) after the initiation of operation, 30 min before the end of operation(T5), and 2 h after operation(T6).
ResultsCompared with group C, serum concentrations of I-FABP in group D were significantly lower at T3-T6[(5.66±012), (6.80±0.18), (6.42±0.70), (5.31±0.21) mg/L vs (6.15±0.35), (7.25±0.13), (6.81±0.65), (6.38±0.14) mg/L](P<0.05), similarly, urine concentrations of I-FABP significantly decreased in group D at T3-T4 and T6 [(6.23±0.15), (6.98±0.20), (5.80±0.15) mg/L vs (6.82±0.10), (7.89±0.53), (6.38±0.14) mg/L](P<0.05).
ConclusionsDex can reduce I-FABP in esophageal cancer patients receiving radical resection, suggesting that it may have protective effects on intestinal barrier.
Key words:
Dexmedetomidine; Esophageal cancer radical resection; Intestinal fatty acid binding protein
Contributor Information
Zhang Ying
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China
Zhang Qi
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Chest Hospital, Shanghai 200030, China
Zhang Xiaofeng
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Chest Hospital, Shanghai 200030, China
Wang Aizhong
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China
Xu Meiying
Department of Anesthesiology, Shanghai Jiaotong University Affiliated Chest Hospital, Shanghai 200030, China