Review Article·Pain Clinic
mGluR5-Homer crosslinking and pain
Luo Limin, Xu Tao, Wang Wenying, Jiang Wei
Published 2018-12-15
Cite as Int J Anesth Resus, 2018,39(12): 1184-1187. DOI: 10.3760/cma.j.issn.1673-4378.2018.12.019
Abstract
BackgroundGroup I metabotropic glutamate receptors (mGluRs), including mGluR1 and mGluR5, are G protein-coupled receptors. Signal transduction of mGluRs regulates chronic pain, emotion, cognition and other complex behaviors, and is a good candidate of drug targets in treatments. Scaffolding proteins Homer influences signal transduction of mGluRs by interacting with the mGluR5 intracellular C terminal TPPSPF motif through its EVH1 domain.
ObjectiveSince mGluR5 plays an essential role in pain, the role of mGluR5-Homer crosslinking on pain adjustment is reviewed.
ContentWe summarized and separately expounded the structure of mGluR5-Homer complex and their regulation of pain.
TrendIt is more convincing that the expression of Homer1a alleviate pain via disassociating of mGluR5-Homer complex.
Key words:
Metabotropic glutamate receptor 5; Homer; Pain
Contributor Information
Luo Limin
Department of Anesthesiology, the Sixth Affiliated People′s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Xu Tao
Department of Anesthesiology, the Sixth Affiliated People′s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Wang Wenying
Department of Anesthesiology, the Sixth Affiliated People′s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
Jiang Wei
Department of Anesthesiology, the Sixth Affiliated People′s Hospital, Shanghai Jiaotong University, Shanghai 200233, China
