Review Article·Basic Research
Neuro-immune communication in acute respiratory distress syndrome: the cholinergic anti-inflammatory pathway
Hairong Xiao, Jiqian Xu, Shanglong Yao, You Shang
Published 2019-05-15
Cite as Int J Anesth Resus, 2019, 40(5): 494-498. DOI: 10.3760/cma.j.issn.1673-4378.2019.05.017
Abstract
The cholinergic anti-inflammatory pathway (CAP) is a pathway that nerve system controls the innate immunity. This pathway plays a critical role in controlling the systematic inflammation. Moreover, this pathway regulates over immune-reaction to the inflammation after acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The review summarized the connotation of the cholinergic anti-inflammatory pathway, their contribution in modulation of ALI/ARDS, such as the new concept--pulmonary parasympathetic inflammatory reflex, as well as cells and molecules which are involved in this process. Considering the perspective of cholinergic anti-inflammatory pathway, we may find new ways for ALI/ARDS treatment.
Key words:
Cholinergic anti-inflammatory pathway; Acute lung injury; Acute respiratory distress syndrome
Contributor Information
Hairong Xiao
Institute of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Jiqian Xu
Institute of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Shanglong Yao
Institute of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
You Shang
Institute of Anesthesia and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Department of Intensive Care Unit, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
