Review Article·Basic Research
Research progress in animal models of postoperative cognitive dysfunction
Fang Xu, Bo Lu, Rongjun Liu, Xiaowei Chen, Junping Chen, Jinwei Zheng, Bo Meng
Published 2019-10-15
Cite as Int J Anesth Resus, 2019, 40(10): 989-995. DOI: 10.3760/cma.j.issn.1673-4378.2019.10.021
Abstract
Postoperative cognitive dysfunction (POCD), of which pathogenesis remains unclear, has many clinical risk factors. A large number of preclinical animal models had been established to investigate the occurrence and development of POCD. Since a wide range of methods of anesthetic drug exposure and surgical types were involved in POCD animal models, further exploring and optimizing POCD animal model are needed for better connecting POCD clinical research with preclinical animal studies. Thus, this review summarizes research progresses on the animal models used in POCD preclinical research in recent years for providing a reference for related POCD preclinical animal research in the future.
Key words:
Postoperative cognitive dysfunction; Animal model; Anesthesia; Surgery
Contributor Information
Fang Xu
Zhejiang Provincial Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Bo Lu
Department of Anesthesiology, Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
Rongjun Liu
Zhejiang Provincial Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Xiaowei Chen
Zhejiang Provincial Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Junping Chen
Department of Anesthesiology, Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
Jinwei Zheng
Department of Anesthesiology, Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
Bo Meng
Department of Anesthesiology, Huamei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China
