Psoriatic arthritis is a chronic, progressive inflammatory arthropathy associated with psoriasis. The specific etiology and pathogenesis of psoriatic arthritis is unknown at present, and some patients with severe psoriatic arthritis do not respond to conventional therapy. Biological agents, such as TNF antagonists, IL-1 antagonists, T cell specific biologic agent, have shown good effects in the treatment of psoriatic arthritis. Also, compared with disease modifying antirheumatic drugs, biologic agents are more effective, tolerable and safer, nevertheless, a variety of adverse reactions have been observed, choice and use of biological agents need to be cautious.