Epidermal growth factor receptor inhibitors (EGFRIs) have shown a satisfactory efficacy in the clinical treatment of tumors. However, cutaneous side effects are often observed during the treatment with EGFRIs, such as acneiform eruption, xerosis, fissures, telangiectasia, hyperpigmentation, hair changes,paronychia, etc. To actively deal with these adverse reactions will improve the compliance of patients during the treatment with EGFRIs. The authors describe clinical manifestations and management of cutaneous side effects associated with EGFRIs, which may facilitate the exploration of new approaches to their management.