Adult-onset Still's disease (AOSD) is a systemic inflammatory disease clinically characterized by regular fever, arthritis or arthralgia, enlarged liver, spleen and lymph nodes, and skin rashes. The etiology of AOSD is still unknown. Of the current diagnostic criteria for AOSD, the Yamaguchi criteria have the highest sensitivity and specificity. Skin involvement is one of the main symptoms of AOSD, and typical transient skin rashes are an important item for the diagnosis of AOSD in the Yamaguchi criteria. Atypical rashes are pleomorphic, including persistent papules/plaques, urticarioid or dermatomyositis-like rashes, etc. Characteristic clinical and pathological manifestations of persistent papules/plaques and urticarioid rashes are helpful for early diagnosis of AOSD. In addition, persistent papules/plaques and dermatomyositis-like rashes may be associated with the severity and prognosis of AOSD.

Still's disease, adult-onset; Skin manifestations; Diagnosis; Pathology; Clinical protocols; Prognosis