Clinical Investigation
Characteristics of cerebral glucose metabolism on 18F-FDG PET imaging in patients with Parkinson′s disease
Chengfeng Jiang, Jingjie Ge, Xinchong Shi, Jianjun Wu, Jian Wang, Ping Wu, Xiangsong Zhang, Chuantao Zuo, Yihui Guan
Published 2017-04-25
Cite as Chin J Nucl Med Mol Imaging, 2017, 37(4): 193-197. DOI: 10.3760/cma.j.issn.2095-2848.2017.04.001
Abstract
ObjectiveTo validate the reproducibility of abnormal cerebral metabolic characteristics in PD patients from different medical centers using 18F-FDG PET imaging.
MethodsA total of 108 subjects who were referred for resting-state brain 18F-FDG PET imaging were retrospectively reviewed. Thirty-three PD patients (15 males, 18 females, age: 38-79 years) and 33 age-matched healthy controls (15 males, 18 females, age: 40-77 years) underwent evaluation at Shanghai Huashan Hospital Affiliated to Fudan University. Seventeen PD patients (10 males, 7 females, age: 44-74 years) and 17 age-matched healthy controls (6 males, 11 females, age: 42-67 years) underwent evaluation at the First Affiliated Hospital of Sun Yat-sen University. SPM was used to investigate the cerebral metabolic characteristics of the patients with two-sample t test. Statistically significant voxels were obtained by using familywise error rate (FWE; P<0.05). Two sets of PD patients with abnormal glucose metabolism of brain regions were obtained and the cerebral metabolic characteristics were compared.
ResultsRegarding the PD patients from Shanghai Huashan Hospital, the features of cerebral glucose metabolism by SPM analysis were demonstrated as follows: increased metabolism was found in the region of pons, cerebellum, thalamus, putamen and pallidum, while decreased metabolism was displayed in the region of parietal lobe and occipital lobe. The increased regions referred to 8 110 voxels and decreased regions referred to 2 810 voxels (P<0.05). The similar metabolic pattern was found in PD patients from the First Affiliated Hospital of Sun Yat-sen University. The increased metabolism was shown in the regions of pons, cerebellum, thalamus, putamen and pallidum, and referred to 15 573 voxels. The metabolism-decreased regions included parietal lobe, occipital lobe and frontal lobe, and referred to 3 945 voxels (P<0.05).
Conclusions18F-FDG PET/CT imaging results demonstrate similar metabolic pattern in PD patients from different medical centers, in whom the metabolism-increased regions are found in the pons, cerebellum, thalamus and pallidum and decreased regions were demonstrated in the parietal lobe and occipital lobe. The reproducibility from 18F-FDG PET/CT imaging provides reliable evidence for the multi-center study in the differential diagnosis of PD.
Key words:
Parkinson disease; Brain; Metabolism; Positron-emission tomography; Deoxyglucose
Contributor Information
Chengfeng Jiang
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Jingjie Ge
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xinchong Shi
Department of Nuclear Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Jianjun Wu
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China
Jian Wang
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200235, China
Ping Wu
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Xiangsong Zhang
Department of Nuclear Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China
Chuantao Zuo
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
Yihui Guan
PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
