PET/CT Imaging in Lymphomas
Value of 18F-FDG PET/CT in the staging, interim therapeutic and prognostic evaluation of mucosa-associated lymphoid tissue lymphoma
Wenli Qiao, Yan Xing, Qinli Qi, Jianhua Song, Taisong Wang, Xiang Chen, Changcun Liu, Jinhua Zhao
Published 2018-09-25
Cite as Chin J Nucl Med Mol Imaging, 2018, 38(9): 588-592. DOI: 10.3760/cma.j.issn.2095-2848.2018.09.002
Abstract
ObjectiveTo assess the value of 18F-fluorodeoxyglucose (FDG) PET/CT in the staging, interim therapeutic and prognostic evaluation of mucosa-associated lymphoid tissue (MALT) lymphoma.
MethodsThirty-six MALT lymphoma patients (20 males, 16 females; average age: 61.7 years) confirmed by pathology from January 2008 to January 2018 were retrospectively analyzed.18F-FDG PET/CT were performed before chemotherapy and radiotherapy for staging. The detective sensitivity was evaluated. The staging results of gastric MALT lymphoma and extragastric MALT lymphoma by PET/CT were compared with Fisher exact probability method. PET/CT was performed in 17 of 36 patients after 4 courses of chemotherapy, and 17 patients were divided into positive group (≥4) and negative group (<4) according to scores of Deauville 5-point scale. The progression-free survival (PFS) was evaluated using Kaplan-Meier survival analysis.
ResultsFDG-positive lesions were found in 31 of 36 patients with the sensitivity of 86.1%(31/36). The results of PET/CT were negative in stageⅠpatients. In stageⅡ-Ⅳ patients, the results of 18F-FDG PET/CT combined with bone marrow biopsy were in accordance with the results of clinical staging. The accuracy of PET/CT in staging of gastric MALT lymphoma patients was 9/17, which was significantly lower than that of extragastric MALT lymphoma patients (17/19; P=0.025). The PFS of negative group evaluated by interim PET/CT was longer than that of positive group (χ2=4.16, P<0.05). The 2-year PFS rates of the 2 groups were (85.7±13.2)% and (27.8 ±21.3)%, respectively. The PFS of patients with low expression of Ki-67 was significantly longer than that of patients with high Ki-67 expression(χ2=4.22, P<0.05).
ConclusionsIn stageⅡ-Ⅳ MALT patients, 18F-FDG PET/CT combined with bone marrow biopsy can improve the staging accuracy. The staging accuracy of PET/CT in extragastric MALT lymphoma is significantly higher than that of gastric MALT lymphoma. PET/CT and Ki-67 can provide effective information on the prognostic evaluation for patients with MALT lymphoma.
Key words:
Lymphoma, B-cell, marginal zone; Neoplasm staging; Prognosis; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose
Contributor Information
Wenli Qiao
Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Yan Xing
Qinli Qi
Jianhua Song
Taisong Wang
Xiang Chen
Changcun Liu
Jinhua Zhao
