Clinical Investigation
Correlation of Glut-1, Glut-3 and HK-Ⅱ expression with 18F-FDG uptake in non-small cell lung cancer and pulmonary inflammatory lesions
Zhenguang Wang, Mingming Yu, Guangjie Yang, Yu Han, Yangyang Wang, Peng Zhao
Published 2018-09-25
Cite as Chin J Nucl Med Mol Imaging, 2018, 38(9): 605-608. DOI: 10.3760/cma.j.issn.2095-2848.2018.09.006
Abstract
ObjectiveTo analyze the expression of glucose transport protein (Glut)-1, Glut-3 and hexokinase (HK)-Ⅱ in non-small-cell lung cancer (NSCLC) lesions and pulmonary inflammatory lesions and discuss the correlation of them with 18F-fluorodeoxyglucose (FDG) uptake.
MethodsTwenty-four patients with NSCLC and 22 patients with pulmonary inflammatory lesions (25 males, 21 females; age range: 37-81 years) who underwent PET/CT from November 2012 to May 2016 were retrospectively analyzed. All patients had surgery and were confirmed by pathology. The expression of Glut-1, Glut-3 and HK-Ⅱ in the lesions was detected by immunohistochemistry. Immunohistochemical staining scores and maximum standardized uptake value (SUVmax) were calculated. One-way analysis of variance, the least significant difference t test, two-sample t test and Spearman correlation analysis were used.
ResultsThe SUVmax of NSCLC lesions was 8.71±7.62, higher than that of pulmonary inflammatory lesions (3.29±2.16; t=3.220, P<0.05). Immunohistochemical staining scores of Glut-1, Glut-3 and HK-Ⅱ were 3.75±0.99, 4.04±1.00 and 4.00±0.78 for NSCLC lesions respectively, and were all higher than those of pulmonary inflammatory lesions (2.32±0.65, 2.89±0.83, 2.41±0.50; t values: 5.340, 5.160, 8.130, all P<0.01). The expression of Glut-1 and HK-Ⅱ was positively correlated with SUVmax in NSCLC lesions (rs values: 0.414, 0.457, both P<0.05). The expression of Glut-1, Glut-3 and HK-Ⅱ was not correlated with SUVmax (rs values: 0.392, 0.070, -0.066, all P>0.05), but the expression of Glut-3 was higher than that of Glut-1 and HK-Ⅱ (F=4.123, t values: 0.970, 0.150, all P<0.05) in pulmonary inflammatory lesions.
ConclusionsThe expression of Glut-1, Glut-3 and HK-Ⅱ is higher in NSCLC lesions than that in pulmonary inflammatory lesions. Glut-1 and HK-Ⅱ are the important factors for 18F-FDG uptake in NSCLC. Glut-3 may play an important role in 18F-FDG uptake in pulmonary inflammatory lesions.
Key words:
Carcinoma, non-small-cell lung; Glucose transport proteins, facilitative; Hexokinase; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose
Contributor Information
Zhenguang Wang
PET/CT Center, the Affiliated Hospital of Qingdao University, Qingdao 266100, China
Mingming Yu
PET/CT Center, the Affiliated Hospital of Qingdao University, Qingdao 266100, China
Guangjie Yang
PET/CT Center, the Affiliated Hospital of Qingdao University, Qingdao 266100, China
Yu Han
Department of Nuclear Medicine, Cangzhou Central Hospital, Cangzhou 061000, China
Yangyang Wang
Department of Nuclear Medicine, the Second Hospital of Shandong University, Jinan 250033, China
Peng Zhao
Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266100, China
