Basic Science Investigation
Synthesis of 18F-PSMA-1007 by one-step method and PET/CT imaging in prostate cancer
Zhou Xing, Shen Taipeng, Yao Yutang, Lu Hao, Chen Shirong, Xiao Dingqiong, Zhao Meng, Xu Guohui, You Jinhui, Cheng Zhuzhong
Published 2019-10-25
Cite as Chin J Nucl Med Mol Imaging, 2019,39(10): 606-609. DOI: 10.3760/cma.j.issn.2095-2848.2019.10.007
Abstract
ObjectiveTo synthesize and analyze 18F-prostate specific membrane antigen (PSMA)-1007, followed by its imaging in prostate cancer.
MethodsBased on one-step method, 18F-PSMA-1007 was produced by the CFN-MPS-200 automatic synthesis module and its quality analysis was conducted. 18F-PSMA-1007 PET/CT imaging was performed in a prostate cancer patient (66 years old).
ResultsThe synthesis time of 18F-PSMA-1007 was about 50 min, and the radiochemical yield was (25.0±5.0) % (attenuation correction, n=3). The radiochemical purity was above 99.0% and was above 98.0% after 6 h. The product was colorless transparent solution with pH value of 7.0-7.5, and the specific activity was (410.0±11.0) MBq/ml and the radioactive nuclear purity was above 99.0%. PET/CT imaging in the patient showed that 18F-PSMA-1007 was highly concentrated in prostate cancer with maximum standardized uptake value (SUVmax) of 40.9.
ConclusionBased on CFN-MPS-200 multifunction synthesis module, 18F-PSMA-1007 can be stably synthesized with high radiochemical yield and can be concentrated in prostate cancer.
Key words:
Prostate neoplasms; Prostate-specific membrane antigen; Fluorine radioisotopes; Chemical synthesis; Positron-emission tomography; Tomography, X-ray computed
Contributor Information
Zhou Xing
School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, China; Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Shen Taipeng
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Yao Yutang
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Lu Hao
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Chen Shirong
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Xiao Dingqiong
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Zhao Meng
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
Xu Guohui
Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
You Jinhui
School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, China
Cheng Zhuzhong
School of Medical Imaging, North Sichuan Medical College, Nanchong 637000, China; Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital & Institute, Chengdu 610041, China
