Review Article
Application of nuclear medical imaging in the diagnosis of myocardial amyloidosis
Jingyun Ren, Shan He, Zhuang Tian, Peng Liu, Li Huo, Fang Li, Shuyang Zhang
Published 2019-12-25
Cite as Chin J Nucl Med Mol Imaging, 2019, 39(12): 759-762. DOI: 10.3760/cma.j.issn.2095-2848.2019.12.013
Abstract
Amyloidosis is a disease caused by abnormal deposition of amyloid protein, and the main types of amyloidosis involving myocardium are light chain amyloidosis (AL) and transthyretin-related amyloidosis (ATTR). Different types of myocardial amyloidosis have different prognosis and treatment methods. Therefore, early diagnosis and classification are particularly important. Nuclear medical imaging can diagnose and classify myocardial amyloidosis noninvasively. Radiotracers for bone scintigraphy has high sensitivity and specificity for the diagnosis of ATTR, and have certain value for prognosis. Sympathetic innervation imaging tracers can detect cardiac sympathetic innervation, which may show myocardial involvement of amyloidosis earlier than bone scintigraphy. Amyloid protein specific imaging agent, which was first used in the diagnosis of amyloidosis in nervous system, has also yielded good results from preliminary studies in myocardial amyloidosis, and the diagnostic specificity in AL is slightly better than that in ATTR. This review introduces the application of nuclear medical imaging in myocardial amyloidosis.
Key words:
Amyloidosis; Myocardium; Radionuclide imaging; Positron-emission tomography; 3-idobenzylguanidine; Amyloid; Trends
Contributor Information
Jingyun Ren
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Shan He
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Zhuang Tian
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Peng Liu
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Li Huo
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Fang Li
Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China
Shuyang Zhang
Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
