131I Therapy for Thyroid Cancer
Efficacy evaluation of percutaneous osteoplasty combined with 131I therapy and survival analysis in patients with bone metastasis from differentiated thyroid carcinoma
Sun Jianwen, Song Hongjun, Xi Chuang, Wu Chungen, Shen Chentian, Qiu Zhongling, Luo Quanyong
Published 2020-06-25
Cite as Chin J Nucl Med Mol Imaging, 2020, 40(6): 339-342. DOI: 10.3760/cma.j.cn321828-20200302-00082
Abstract
ObjectiveTo explore the efficacy of percutaneous osteoplasty (POP) combined with 131I therapy in patients with bone metastases from differentiated thyroid carcinoma (DTC) and assess the survival.
MethodsFrom Januray 2008 to January 2020, 29 DTC patients with bone metastases (16 males, 13 females, age range: 24-64 years) who received POP combined with 131I therapy in Shanghai Sixth People′s Hospital were retrospectively analyzed. Clinical data and characteristics of patients were analyzed. The efficacy and prognosis were evaluated based on the changes of serum thyroglobulin (Tg) and relieving condition of bone pain after the combined treatment. χ2 test was used to determine the association between clinical characteristics and efficacy, and Kaplan-Meier analysis was used to estimate the overall survival (OS) rate.
ResultsThe biochemical response rate of serum Tg was 68.97% (20/29) after the combined treatment. For the influence on changes of serum Tg, whether or not combined with non-osseous distant metastasis, and cumulative dose of 131I treatment(≥22.2 vs <22.2 GBq) were statistically significant ( χ2 values: 5.448 and 4.371, both P<0.05). The rate of bone pain relief was 65.52%(19/29). Age (≥55vs <55 years) and the cumulative dose of 131I treatment had statistically influences on bone relief (χ2 values: 7.486 and 5.154, both P<0.05). The 5-years OS rate of patients was 87.68%, while the 10-years OS rate was 65.76%.
ConclusionPOP combined with 131I therapy is effective on relieving the pain, reducing the serum Tg to some extent, and improving the long-term survival of DTC patients with bone metastasis.
Key words:
Thyroid neoplasms; Neoplasm metastasis; Skeleton; Radiotherapy; Iodine radioisotopes; Cementoplasty; Treatment outcome
Contributor Information
Sun Jianwen
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Song Hongjun
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Xi Chuang
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Wu Chungen
Department of Interventional Radiology, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Shen Chentian
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Qiu Zhongling
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
Luo Quanyong
Department of Nuclear Medicine, Shanghai Sixth People′s Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
