To evaluate correlation between left ventricular mechanical contraction synchrony and left ventricular systolic function by gated myocardial perfusion imaging(GMPI) using Cadmium-Zine-Telluride (CZT) SPECT.

Three hundred and forty three consecutive patients( 232 males, 111 females, age (60.08±12.88) years) who underwent CZT SPECT GMPI in Shanxi Cardiovascular Hospital between January and August 2019 were retrospectively analyzed. The Emory cardiac toolbox was used to process the imaging data, and the left ventricular systolic synchrony parameters and systolic function parameters were acquired, including peak phase(PP), phase standard deviation (PSD), phase histogram bandwidth(PHB), histogram skewness(HS), histogram kurtosis(HK), and end-diastolic volume( EDV), end-systolic volume (ESV), left ventrieular ejection fraction (LVEF). All patients were divided into 4 groups: the normal group (147 cases), ischemic cardiomyopathy group (114 cases), nonischemic cardiomyopathy without left bundle branch block (LBBB) group(50 cases)and nonischemic cardiomyopathy with LBBB group(32 cases). The relationship between systolic synchrony parameters and systolic function parameters were analyzed with Pearson correlation analysis.

Statistic results for all patients showed that PSD and PHB were well correlated with LVEF(r values: -0.790, -0.799, both P<0.01), but PP was poorly correlated with LVEF(r=-0.194, P<0.01); HS, HK were positively correlated with LVEF(r values: 0.767, 0.676, both P<0.01); PSD, PHB were positively correlated with ESV(r values: 0.778, 0.795, both P<0.01) and EDV (r values: 0.722, 0.732, both P<0.01); but PP was poorly correlated with ESV(r=0.145, P<0.01) and not correlated with EDV (r=0.095, P>0.01). HS, HK were negatively correlated with EDV and ESV (r values: -0.700 to -0.580, all P<0.01). PSD and PHB showed negatively correlation with LVEF (r values: -0.834 to -0.492, all P<0.01), while HS, HK showed positive correlation with LVEF (r values: 0.243-0.792, all P<0.01) in normal group, the ischemic cardiomyopathy group, the nonischemic cardiomyopathy without LBBB group and the nonischemic cardiomyopathy with LBBB group.

The left ventricular systolic synchrony parameters provided by CZT SPECT GMPI correlate well with the left ventricular systolic function parameters, and the worse systolic function, the worse systolic synchrony. Both ischemic cardiomyopathy and non-ischemic cardiomyopathy can affect left ventricular mechanical contraction synchrony, and the effect on contraction synchrony in non-ischemic cardiomyopathy patients with LBBB is greater.

Myocardial contraction; Ventricular function, left; Myocardial perfusion imaging; Tomography, emission-computed, single-photon; Technetium Tc 99m sestamibi