Clinical Investigation
Efficacy of 18F-FDG PET/CT in the differential diagnosis of benign and malignant solitary pulmonary nodules
Liu Yong, Chen Peng, Sun Zhenguo, Yuan Xiaoshuai, Du Peng, Song Changxiang, Lu Wu
Published 2020-07-25
Cite as Chin J Nucl Med Mol Imaging, 2020, 40(7): 411-414. DOI: 10.3760/cma.j.cn321828-20191125-00182
Abstract
ObjectiveTo analyze the value of maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose (FDG) PET/CT in differentiating the malignant solitary pulmonary nodules (SPN) from benign ones.
Methods18F-FDG PET/CT imaging data of 84 patients (39 males, 45 females; age: 34-81(average: 61.1) years) with SPN in the First People′s Hospital of Lianyungang between September 2017 and June 2019 were retrospectively analyzed. The pathological results were taken as the gold standard. Differences of SUVmax between benign and malignant SPN were analyzed with Mann-Whitney U test, and the best cut-off value for the diagnosis of benign and malignant SPN was measured by receiver operating characteristic (ROC) curve. The diagnostic efficacy was analyzed based on SUVmax.
ResultsThe pathological results confirmed 54 patients with malignant SPN, and 30 patients with benign SPN. SUVmax of malignant group was significantly higher than that of benign group (5.48±4.08 vs 1.70(0.73, 3.33); U=443.50, P=0.001). The 84 SPN included 58 solid SPN and 26 subsolid SPN. SUVmax of malignant subsolid SPN and benign ones were not significantly different (U=56.00, P>0.05). The diagnostic value of SUVmax in 58 cases of solid nodules were analyzed based on ROC curves, and the optimal cut-off value was 1.85. The corresponding diagnostic sensitivity, specificity, accuracy, negative predictive value and positive predictive value were 97.06%(33/34), 62.50%(15/24), 82.76%(48/58), 15/16, 78.57%(33/42), respectively.
Conclusions18F-FDG uptake of malignant SPN were higher than benign ones. The diagnosis of benign and malignant solid SPNs based on SUVmax 1.85 has high sensitivity, negative predictive value and accuracy. SUVmax has limited diagnostic value on subsolid SPN.
Key words:
Solitary pulmonary nodule; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose
Contributor Information
Liu Yong
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Chen Peng
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Sun Zhenguo
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Yuan Xiaoshuai
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Du Peng
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Song Changxiang
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
Lu Wu
Department of Nuclear Medicine, the First People′s Hospital of Lianyungang, Lianyungang 222002, China
