Clinical Investigation
Quantitative evaluation of the diffusion characteristics of calf muscles in type 2 diabetic mellitus patients by diffusion tensor imaging
Fu Yunlei, Guan Shiming, Qi Huihui, Gu Jing, Li Wei, Zhang Zhuiyang
Published 2020-12-25
Cite as Chin J Nucl Med Mol Imaging, 2020, 40(12): 716-720. DOI: 10.3760/cma.j.cn321828-20191022-00228
Abstract
ObjectiveTo explore the quantitative analysis value of diffusion tensor imaging (DTI) for early changes of calf muscle in type 2 diabetes mellitus (T2DM) patients without peripheral ischemia.
MethodsFrom September 2018 to March 2019, 20 male T2DM patients (age: 45-64 years) without peripheral ischemia and 20 matched male healthy controls (age: 46-62 years) who performed lower limb DTI in Wuxi Second Hospital Affiliated to Nanjing Medical University were prospectively analyzed. Fractional anisotropy (FA), apparent diffusion coefficient (ADC) and λ 1, λ 2, λ 3 values of medial head of gastrocnemius (GM), lateral head of gastrocnemius (GL), tibialis anterior(TA) and soleus muscles(SOL) were measured respectively. The differences of DTI diffusion characteristics between 2 groups were compared by using independent-sample t test, and the correlation between FA, ADC and body mass index (BMI), fasting blood glucose (FBG), hemoglobin A 1c (HbA1c), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) were analyzed by Pearson correlation analysis.
ResultsThe ADC of TA and SOL in T2DM group ((1.77±0.15) and (1.83±0.10)×10-3 mm2/s) was higher than that in control group ((1.66±0.11) and (1.75±0.16)×10-3 mm2/s); λ 1, λ 2, and λ 3 of TA in the T2DM group ((2.30±0.21), (1.63±0.17) and (1.38±0.13)×10-3 mm2/s) were higher than those in control group ((2.17±0.12), (1.51±0.13) and (1.31±0.12)×10-3 mm2/s); λ 2 and λ 3 of SOL were also higher than those in control group ((1.74±0.11) vs (1.64±0.18)×10-3 mm2/s and (1.53±0.12) vs (1.44±0.15)×10-3 mm2/s; t values: 2.65-3.91, all P<0.05). There were no significant correlations between FA, ADC and BMI, FBG, HbA1c, HDL, LDL and TG (r values: from -0.15 to 0.08, all P>0.05).
ConclusionsQuantitative parameters of DTI, especially ADC, can sensitively detect the microstructural changes of calf muscle in T2DM patients without peripheral ischemia. TA and SOL have high sensitivity to the diffusion of T2DM-related microstructural changes.
Key words:
Diabetes mellitus, type 2; Diffusion tensor imaging; Muscles; Leg
Contributor Information
Fu Yunlei
Department of Radiology, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China
Guan Shiming
Department of Medicine, Huadong Sanatorium, Wuxi 214042, China
Qi Huihui
Department of Medicine, Huadong Sanatorium, Wuxi 214042, China
Gu Jing
Department of Medicine, Huadong Sanatorium, Wuxi 214042, China
Li Wei
Department of Radiology, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China
Zhang Zhuiyang
Department of Radiology, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China
