Wei Maomao, Liu Weiping, Yuan Tingting, Song Jinling, Song Yuqin, Zhu Jun, Yang Zhi, Wang Xuejuan
Abstract
ObjectiveTo explore the role of 18F-fluorodeoxyglucose (FDG) PET/CT in early detection of therapy-associated cardiotoxicity (TACT) in lymphoma patients and to analyze the diagnostic efficacy of different evaluation criteria.
MethodsConsecutive patients between November 2009 to October 2018 in Peking University Cancer Hospital were retrospectively enrolled. All patients underwent standard chemotherapy. Myocardial uptake of 18F-FDG pre- and post-treatment were analyzed by visual interpretation and semi-quantitative (maximum standardized uptake value, SUVmax) methods. The value of pre-treatment SUVmax-heart -post-treatment SUVmax-heart (ΔSUVmax), %ΔSUVmax, and post-treatment SUVmax-heart/SUVmax-mediastinum, SUVmax-heart/SUVmax-liver and SUVmax-heart/SUVmax-background(left gluteal muscle) ratios were calculated. Receiver operating characteristic (ROC) curve analysis was performed to determine optimal cut-off values of those PET/CT imaging criteria for evaluating early TACT of lymphoma, taking electrocardiogram (ECG) positive as the end point. Independent-sample t test and χ2 test were performed.
ResultsA total of 274 patients (median age was 36-year old), with the male-to-female ratio of 1.85∶1, were included, and 78.1%(214/274) of them had non-Hodgkin′s lymphoma (NHL). After treatment, 55.1%(151/274)of the patients had high myocardial uptake of 18F-FDG (compared with liver uptake), 20.4%(56/274) of them had moderate myocardial uptake (between liver uptake and blood-pool uptake), and 24.5%(67/274) were with equal uptake (less than blood-pool uptake). There were significant differences in myocardial uptake between ECG-positive group (n=71) and ECG-negative group (n=203) ( SUVmax: 7.77±4.06 vs 5.91±3.04; t=4.045, P<0.01). ROC curves showed that optimal thresholds of post-treatment SUVmax-heart, Δ SUVmax-heart, %ΔSUVmax-heart, and post-treatment SUVmax-heart/SUVmax-mediastinum, SUVmax-heart/SUVmax-liver and SUVmax-heart/SUVmax-background ratios were 9.4, 4.8, 1.4, 5.0, 2.3, 7.0 respectively. The corresponding areas under the curves (AUC) were 0.653, 0.637, 0.612, 0.655, 0.649 and 0.650, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of post-treatment SUVmax-heart/SUVmax-background ratio were 40.85%(29/71), 82.76%(168/203), 45.31%(29/64), 80.00%(168/210) and 71.90%(197/274).
Conclusion18F-FDG PET/CT can early detect TACT in patients with lymphoma, and if using 7.0 as the threshold of post-treatment SUVmax-heart/SUVmax- background ratio, the specificity and negative predictive value of 18F-FDG PET/CT for early prediction of TACT are up to 80%.
Key words:
Cardiotoxicity; Lymphoma; Drug therapy; Positron-emission tomography; Tomography, X-ray computed; Deoxyglucose
Contributor Information
Wei Maomao
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Liu Weiping
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Yuan Tingting
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Song Jinling
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Song Yuqin
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Zhu Jun
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Yang Zhi
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital &
Institute, Beijing 100142, China
Wang Xuejuan
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital &
Institute, Beijing 100142, China