Clinical Investigation
Prognostic value of pretreatment 18F-FDG PET/CT in patients with primary malignant melanoma
Lai Ruihe, Zhao Lianjun, Sun Yiwen, Teng Yue, Li Aimei, Xu Shoulin, Jiang Chong
Published 2022-03-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(3): 144-148. DOI: 10.3760/cma.j.cn321828-20200915-00345
Abstract
ObjectiveTo assess the prognostic value of pretreatment 18F-FDG PET/CT metabolic parameters in patients with primary melanoma.
MethodsA retrospective analysis comprised of 35 patients (21 males, 14 females, age: 35-85 years; from January 2014 to August 2019; Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School) who were newly-diagnosed primary melanoma with preoperative 18F-FDG PET/CT was conducted. 18F-FDG PET/CT metabolic parameters including SUVmax, SUVmean, peak of SUV (SUVpeak) were obtained. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of primary focus were measured automatically using the threshold of 40%SUVmax. The optimal thresholds of PET parameters were obtained by using ROC curve analysis. The associations between melanoma-specific survival (MSS), progression-free survival (PFS) and PET/CT metabolic parameters were assessed using Kaplan-Meier method and Cox proportional hazards model.
ResultsThe median follow-up was 15.4 months, and 20 patients showed disease progression and 7 died. The cut-off values for SUVmax, SUVmean, SUVpeak, MTV and TLG were 3.95, 2.45, 2.65, 3.60 cm3 and 14.85 g, respectively (AUCs: 0.742, 0.790, 0.728, 0.655, 0.693; P values: 0.016, 0.004, 0.022, 0.121, 0.053). Kaplan-Meier method and log-rank test showed that SUVmax, SUVmean, SUVpeak, MTV and TLG were predictors of PFS (χ2 values: 4.06-8.35, all P<0.05). Multivariate analysis showed that MTV (hazard ratio (HR)=3.09, 95% CI: 1.08-8.86, P=0.036) and TLG (HR=3.36, 95% CI: 1.11-10.14, P=0.031) were significant predictors of PFS but not for MSS (HR=5.14, P=0.080).
ConclusionsSUVmax, SUVmean and SUVpeak of primary focus may help for predicting PFS of patients with primary melanoma. MTV and TLG of primary focus may be the best to predict PFS of primary melanoma.
Key words:
Melanoma; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18
Contributor Information
Lai Ruihe
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
Zhao Lianjun
The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Sun Yiwen
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
Teng Yue
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
Li Aimei
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
Xu Shoulin
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
Jiang Chong
Department of Nuclear Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 21008, China
