New Domestic Radionuclides
Preparation of no-carrier-added 161Tb by lanthanide resin
Zhao Peng, Zhuo Liangang, Guo Xiaoyu, Dang Yufeng, Li Gang, Wang Jing, Yang Xia, Liao Wei, Li Hongbo, Xiong Xiaoling, Lin Qingchuan, Wei Hongyuan, Tu Jun, Yang Yuchuan
Published 2022-06-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(6): 325-329. DOI: 10.3760/cma.j.cn321828-20220217-00049
Abstract
ObjectiveTo produce 161Tb from enriched 160Gd2O3 isotope-enriched target material and realize domestic production of the novel medical isotope 161Tb.
MethodsThe 160Gd2O3 isotope-enriched target material was irradiated with neutrons by the China Mianyang Research Reactor (CMRR). The no-carrier-added 161Tb product was obtained after the processes of target broken, sample dissolution, separation and purification with lanthanide (LN) resin and solution replacement with diglycolamide (DGA) column. Various key indicators such as γ spectral purity, metal impurity content, specific activity, radiochemical purity, and radioactive concentration were used to conduct the quality inspection and the control of 161Tb products.
Results161TbCl3 of 33.4 GBq was obtained in a single time with the radioactive concentration of 16.8 GBq/ml, nuclear purity more than 99.9%, and radiochemical purity of 99.2%. Metal impurity content was met the established standards, with the specific activity of 6.02×1017 Bq/mol. The radiochemical purities of 161Tb labeling with 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid-D-Phe1-Tyr3-Thr8-octreotide (DOTATATE) after 0 and 72 h were 100% and 95.8% respectively.
ConclusionThe preparation of no-carrier-added 161Tb by using LN resin has the advantages of high separation performance and high sample loading, which has great significance in the field of medical isotope preparation and lays a good nuclide guarantee for the research and development of domestic 161Tb-labeled drugs.
Key words:
Lanthanoid series elements; Resins, synthetic; Terbium; Gadolinium
Contributor Information
Zhao Peng
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Zhuo Liangang
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Guo Xiaoyu
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Dang Yufeng
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Li Gang
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Wang Jing
NHC Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL), Mianyang 621099, China
Yang Xia
Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, Mianyang 621999, China
Liao Wei
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Li Hongbo
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Xiong Xiaoling
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Lin Qingchuan
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Wei Hongyuan
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Tu Jun
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
Yang Yuchuan
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621999, China
