Clinical Investigation
Multimodal study on cerebral functional imaging under sleep deprivation
Xuan Ang, Fu Chang, Sun Mengmeng, Wang Li, Xu Junling
Published 2022-07-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(7): 391-396. DOI: 10.3760/cma.j.cn321828-20201206-00435
Abstract
ObjectiveTo reveal the specific region location of brain function injury after sleep deprivation by exploring cerebral glucose metabolism and blood perfusion changes and the correlation between them in healthy volunteers of sleep deprivation.
MethodsFrom January 2019 to December 2019, a total of 17 healthy volunteers (8 males, 9 females; age (22.5±1.7) years) from People′s Hospital of Zhengzhou University were enrolled prospectively. All patients accepted MRI three-dimensional (3D) arterial spin labeling (ASL) and 18F-FDG PET/CT scanning at 2 h after normal sleep and after sleep deprivation of 24 h. Statistical parametric mapping (SPM) software was used for image processing, and brain metabolism and perfusion differences activation graphs before and after sleep deprivation were obtained respectively. Then the common activated brain regions were obtained as ROI. The cerebral blood flow (CBF) and the SUV ratio (SUVR; the cerebellum was the reference area) were calculated. Pearson correlation analysis and paired t test were used for data analysis.
ResultsThe cerebral metabolism and perfusion of the subjects after sleep deprivation were reduced, and the abnormal brain areas were similar. Brain areas with reduced metabolism were more than those with reduced perfusion. The brain areas with reduced metabolism and perfusion after sleep deprivation were commonly in the frontal lobe, temporal lobe, parietal lobe, etc. The CBF and SUVR value of left dorsolateral frontal gyrus after sleep deprivation were correlated (r=0.58, P=0.014). The mean CBF value ((46.32±7.39) ml·100 g-1·min-1) and SUVR value (1.46±0.04) of whole brain after sleep deprivation were lower than those before sleep deprivation ((54.91±6.51) ml·100 g-1·min-1, 1.53±0.06; t values: -2.67, -3.72, P values: 0.012, 0.001).
ConclusionsThe specific region′s location of brain function injury after sleep deprivation is preliminarily revealed. 18F-FDG PET/CT was more sensitive than 3D-ASL for brain function research of sleep deprivation and left dorsolateral frontal gyrus may be a key responsible functional region in subjects of sleep deprivation.
Key words:
Sleep deprivation; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18; Magnetic resonance imaging
Contributor Information
Xuan Ang
Department of Nuclear Medicine, People′s Hospital of Zhengzhou University, Henan Provincial People′s Hospital, People′s Hospital of Henan University
Henan Key Laboratory of Novel Molecular Probes and Clinical Translation in Nuclear Medicine, Zhengzhou 450003, China
Fu Chang
Department of Nuclear Medicine, People′s Hospital of Zhengzhou University, Henan Provincial People′s Hospital, People′s Hospital of Henan University
Henan Key Laboratory of Novel Molecular Probes and Clinical Translation in Nuclear Medicine, Zhengzhou 450003, China
Sun Mengmeng
Department of Nuclear Medicine, People′s Hospital of Zhengzhou University, Henan Provincial People′s Hospital, People′s Hospital of Henan University
Henan Key Laboratory of Novel Molecular Probes and Clinical Translation in Nuclear Medicine, Zhengzhou 450003, China
Wang Li
Medicine Research and Translation Center, Academy of Medical Sciences of Henan Province, Zhengzhou 450003, China
Xu Junling
Department of Nuclear Medicine, People′s Hospital of Zhengzhou University, Henan Provincial People′s Hospital, People′s Hospital of Henan University
Henan Key Laboratory of Novel Molecular Probes and Clinical Translation in Nuclear Medicine, Zhengzhou 450003, China
