Clinical Investigation
Value of 18F-FDG PET/CT in the differential diagnosis of nasopharyngeal carcinoma and nasopharyngeal lymphoma
Fu Qiang, Liu Jianjing, Li Xiaofeng, Chen Wei, Xu Wengui
Published 2022-10-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(10): 588-592. DOI: 10.3760/cma.j.cn321828-20210705-00221
Abstract
ObjectiveTo explore the value of 18F-FDG PET/CT in the differential diagnosis of nasopharyngeal carcinoma and nasopharyngeal lymphoma.
MethodsA retrospective analysis including 100 patients (77 males, 23 females, age (51.0±12.4) years) with nasopharyngeal carcinoma and 107 patients(61 males, 46 females, age (52.3±18.2) years) with nasopharyngeal lymphoma after 18F-FDG PET/CT at Tianjin Medical University Cancer Institute and Hospital from October 2011 to December 2019 was performed. All patients were confirmed by pathology. Differences of clinical data, PET metabolic parameters and CT morphology between nasopharyngeal carcinoma group and nasopharyngeal lymphoma group were compared (independent-sample t test or Mann-Whitney U test). Multiple regression analysis and ROC curve analysis were used to evaluate the efficacy of the combined features in the differential diagnosis of nasopharyngeal carcinoma and nasopharyngeal lymphoma.
ResultsAs for nasopharyngeal carcinoma group and nasopharyngeal lymphoma group, there were statistically significant differences in SUVmax (10.86±3.99 vs 14.81±7.24; t=-4.90, P=0.001), peak of SUV (SUVpeak; 7.84±3.13 vs 10.86±5.66; t=-4.79, P=0.001), and total lesion glycolysis (TLG; 39.00(19.98, 62.56) vs 56.75(33.02, 102.06) g; z=-3.24, P=0.001). However, the diagnostic efficiencies were low (AUCs: 0.657, 0.646, 0.636, respectively). Multiple regression model showed that SUVmax combined with multiple morphological and clinical features (gender, lesion location, with or without involvement of surrounding structures, cervical lymph node metastasis, parapharyngeal involvement and spleen involvement) could improve the differential diagnosis efficiency significantly (AUC=0.900).
Conclusion18F-FDG PET/CT metabolic parameter SUVmax combined with CT morphological and clinical features have high diagnostic efficiency in the differential diagnosis of nasopharyngeal malignant tumors.
Key words:
Nasopharyngeal neoplasm; Lymphoma; Nasopharynx; Positron-emission tomography; Tomography, X-ray computed; Fluorodeoxyglucose F18
Contributor Information
Fu Qiang
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital
National Clinical Research Center for Cancer
Tianjin′s Key Laboratory of Cancer Prevention and Therapy
Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Liu Jianjing
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital
National Clinical Research Center for Cancer
Tianjin′s Key Laboratory of Cancer Prevention and Therapy
Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Li Xiaofeng
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital
National Clinical Research Center for Cancer
Tianjin′s Key Laboratory of Cancer Prevention and Therapy
Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Chen Wei
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital
National Clinical Research Center for Cancer
Tianjin′s Key Laboratory of Cancer Prevention and Therapy
Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Xu Wengui
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital
National Clinical Research Center for Cancer
Tianjin′s Key Laboratory of Cancer Prevention and Therapy
Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
