Review Article
Research progress of salivary glands injury secondary to 225Ac/177Lu-PSMA-617 in the treatment of prostate cancer and its protection
Fu Wenhui, Xu Tingting, Liu Huipan, Zhang Xinyi, Zeng Chengrun, Chen Yue
Published 2022-10-25
Cite as Chin J Nucl Med Mol Imaging, 2022, 42(10): 628-632. DOI: 10.3760/cma.j.cn321828-20210409-00105
Abstract
Prostate specific membrane antigen (PSMA) radioligand therapy (RLT) is effective in metastatic castration-resistant prostate cancer (mCRPC). However, PSMA RLT can cause radiation damage to salivary glands, especially 225Ac/177Lu-PSMA-617. Radiation-related salivary glands damage can cause xerostomia, reduce the quality of life, and even limit the dose of radiopharmaceuticals and reduce the efficacy of tumor treatment. At present, there are few literatures on PSMA RLT related salivary glands damage in China. In this article, radiation-related salivary glands damage and the related protective measures during 225Ac/177Lu-PSMA-617 RLT are reviewed based on domestic and foreign studies.
Key words:
Prostatic neoplasms; Salivary glands; Prostate-specific membrane antigen; Radiotherapy; Actinium; Lutetium; Trends
Contributor Information
Fu Wenhui
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
Xu Tingting
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
Liu Huipan
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
Zhang Xinyi
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
Zeng Chengrun
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
Chen Yue
Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province
Academician (Expert) Workstation of Sichuan Province, Luzhou 646000, China
