Objective To explore the impact of standardized treatment of syphilis in early pregnancy on perinatal infantile outcome.Methods The clinical data of 51 patients with pregnancy complicated by syphilis who received standardized protocol for treatment of syphilis were retrospectively analyzed.They were diagnosed as having syphilis when they had routine prenatal examination at 12 weeks of pregnancy and received the corresponding treatment immediately.Eleven pregnant patients with syphilis who did not receive any intervention were selected as controls.Results Fifty-one patients with early intervention gave birth to 51 neonates,among which 50 were fullterm births and the rest one was preterm infant; no abortion and dead fetus occurred.Serum treponema palidum particle agglutination test (TPPA) was detected positive and rapid plasma regain test (RPR) was detected negative in 21 neonates; both of TPPA and RPR were detected positive (titers≤l∶8) in 11 neonates; the positive index were all found conversion to negative after 1-6 month follow-up.Of 1 1 controls,9 (81.82％) had stillbirth,neonatal death,or congenital syphilis.The incidence of adverse pregnant outcomes in floating pregnancy was 30.43％ (7/23),which was significantly higher than that of local pregnant women [7.69％ (3/39),x2=5.53,P＜0.05]; the rate in cases who did not have any regular job was 24.32％ (9/37),which was significantly higher than that in cases who had regular ones [4.00％(1/25),x2=4.55,P＜0.05].Conclusions The treatment of syphilis in early pregnancy can improve the outcome of pregnancy.To strengthen the follow-up of pregnant women,especially those in floating population,can avoid adverse outcomes of pregnancy complicated by syphilis.