Original Article
Effect of antiretroviral therapy in AIDS patients in Jiaxing of Zhejiang from 2004 to 2015
Xiang Zelin, Luo Jianyong, Ge Rui, Yan Yong, Zhang Qianqian, Xu Wenxian, Hu Jie, Guo Jinlei, Xuan Hua
Published 2017-12-25
Cite as Inter J Epidemionl Infect Dis, 2017,44(6): 374-377. DOI: 10.3760/cma.j.issn.1673-4149.2017.06.004
Abstract
ObjectiveTo observe the HAART effect on AIDS patients in Jiaxing, Zhejiang.
MethodsA total of 175 AIDS patients with HAART from 2004 to 2015 in Jiaxing were collected by retrospective survey. The patients according to baseline CD4+T lymphocyte cell count were divided into low level group (≤200 cells/μL, 114 cases) and high level group (201-305 cells/μL, 61 cases) . The data of CD4+T lymphocyte cell count and HIV load during therapeutic process were collected, and HIV viral load inhibition rate and failure rate were calculated. The relationship between CD4+T lymphocyte count and viral load was analyzed.
ResultsThe level of CD4+T lymphocyte in 175 AIDS patients increased remarkably with the increase of treatment time (Linear regression test b=0.237, F=176.400, P<0.01) and the peak level was at the 48th month [ (372.26±162.44) cells/μL]. The HIV inhibition rate was rising (χ2trend=15.636, P<0.01) , and the HAART failure rate showed a downward trend (χ2trend=9.218, P<0.01) . The CD4+ T lymphocyte count and viral inhibition rate in low and high level groups showed upward trends with the increaseof treatment time (Flinearity=176.889, 37.308; χ2trend=11.571, 5.610; P<0.05 or P<0.01) . The HAART failure rate in low level group showed a downward trend with the time prolonged (χ2trend=6.785, P<0.05) . There were no significantly statistical differences in CD4+ T lymphocyte growth, HIV inhibition rate and HAART failure rate between two groups (P>0.05) . The CD4+T lymphocyte count was negatively correlated with HAART failure rate (r=-0.943, P<0.05) .
ConclusionsThe antiretroviral therapy has a remarkable effectiveness on AIDS patients in Jiaxing from 2004 to 2015. It is effective to enroll patients with CD4+ T lymphocyte count of 201-350 cells/μL in antiretroviral therapy.
Key words:
Acquired immunodeficiency syndrome; Highly active antiretroviral therapy; Effect
Contributor Information
Xiang Zelin
Department of Immunology, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Luo Jianyong
Office, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Ge Rui
Department of AIDS, STD, Tuberculosis Prevention and Control, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Yan Yong
Laboratory, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Zhang Qianqian
Department of AIDS, STD, Tuberculosis Prevention and Control, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Xu Wenxian
Department of AIDS, STD, Tuberculosis Prevention and Control, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Hu Jie
Department of AIDS, STD, Tuberculosis Prevention and Control, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Guo Jinlei
Laboratory, Jiaxing Center for Disease Control and Prevention, Jiaxing 314050, Zhejiang, China
Xuan Hua
Department of Infectious Disease Control, Jiaxing No.1 People’s Hospital, Jiaxing 314050, Zhejiang, China
