Gonococcal Infection and Antimicrobial Resistance·Review
Research progress in molecular epidemiology of gonorrhea
Yang Yunqing, Zhu Huilan, Luo Quan, Tang Shaokai, He Wanping, Liang Rongjiao, Zhong Xuelian, Peng Jiajun, Wang Jianqin, Chen Xiangsheng
Published 2019-08-25
Cite as Inter J Epidemionl Infect Dis, 2019,46(4): 322-326. DOI: 10.3760/cma.j.issn.1673-4149.2019.04.016
Abstract
Gonorrhoea is a sexually transmitted disease caused by Neisseria gonorrhoeae infection of the human reproductive tract. Along with the rapid increase of both incidence and drug resistance, gonorrhoea has been one of the global public health problems. With the development of nucleic acid detection, the gonococcal typing technology has gradually become an important research tool in the molecular epidemiology of gonorrhea. This review summarizes recent advances in molecular epidemiology of gonorrhea, including the common typing methods based on DNA gel electrophoresis and sequence sequencing, and the application of these methods in the resistance detection and sexual network, so as to promote the further exploration of treatment therapy and control protocol for gonorrhea.
Key words:
Neisseria gonorrhoeae; Molecular epidemiology; Typing; Sexual network
Contributor Information
Yang Yunqing
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Zhu Huilan
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Luo Quan
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Tang Shaokai
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
He Wanping
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Liang Rongjiao
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Zhong Xuelian
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Peng Jiajun
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Wang Jianqin
Guangzhou Institute of Dermatology China, Guangzhou 510095, China
Chen Xiangsheng
Institute of Dermatology, Chinese Academy of Medical Sciences; National Center for STD Control, China CDC, Nanjing 210042, China