Objective To explore the role of hypothermia in curing patients with acute cerebral infarction. Methods 40 patients with final diagnosis of acute cerebral infarction in our department from 2007-3 ～ 2009-1 were selected and randomly divided into hypothermia group and normathermia group. Both groups were treated with the same approach except the hypothermal intervention in hypothermia group. Prognosis,infarct size and the rate of revas-cularization were compared between the groups after 1 month following up. Results When compared with the normathermia group,the hypothermia group had better prognosis and less infarct size after treating,but statistical significance could not find in two groups in the rate of revascularization. Conclusion Under a series of mechanism,hypothermia could grow down the local infarct size and make important sense to improve the prognosis of patients with acute cerebral infarction.