Comparison of the effect of intervention embolization and operation in the treatment of cerebral aneurysms
GUO Qiang, JIN Feng, CHEN De-qin, YAN Shi-qing, KONG Ling-sheng, ZHANG Hao, HAN Guang-kui
Published 2012-09-15
Cite as Chin J Prim Med Pharm, 2012,19(18): 2725-2727. DOI: 10.3760/cma.j.issn.1008-6706.2012.18.003
Abstract
Objective To compare of intervention embolization and operation in the treatment of brain aneurysms.Methods 60 cerebral aneurysm patients using random number table method were divided into two groups each 30 cases,group A given intervention embolization;group B given surgical operation treatment.They were followed for 3months,the bleed Glasgow results score,matrix metalloproteinases 2(MMP-2) level change and the length of time were recorded.Results After treatment,A group total effective rate was 73.4%,postoperative treatment to bleed again rate was 10.0% (3/30),B group was 76.7%,6.7% (2/30),two groups had no statistically significant differences (x2 =0.09,0.22,all P > 0.05 ) before treatment M MP-2 level between ;The two groups was statistically significant ( t =1.21,P > 0.05 ) ;Two groups after surgical treatment 3 d MMP-2 levels were ( 20.1 ± 8.7 ) μg/L,( 35.7 ±8.9 ) μg/L respectively,which was statistically significant ( t =3.33,P < 0.05 ).A group of hospitalization time (8.6 ±1.5 ) d,group B ( 13.2 ± 1.3 ) d,the difference between two groups was statistically significant ( t =3.18,P < 0.05 ).Conclusion For brain aneurysm patients,the intervention embolization had no obvious difference in curative effect with operation,but could reduce the time in hospital and significantly reduced MMP-2 level.
Key words:
Intracranial aneurysms; Embolization,therapeutic; Nerve surgery
Contributor Information
GUO Qiang
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
JIN Feng
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
CHEN De-qin
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
YAN Shi-qing
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
KONG Ling-sheng
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
ZHANG Hao
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China
HAN Guang-kui
Department of Neurosurgery,the Affiliated Hospital of Jining Medical College ,Jining,Shandong 272029, China