To observe the safety and efficacy of rocuronium rapid sequence induction in patient undergoing laparoscopic cholecystectomy(LC).

100 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups(n=50):control group(group C)and rocuronium rapid sequence induction group (group R).Conventional induction of anesthesia was used in group C,rocuronium rapid sequence induction was used in group R and assisted ventilation was not implemented in the induction process. Oxygen saturation(SpO₂), partial pressure of oxygen(PaO₂), carbon dioxide partial pressure(PaO₂),p H were recored at the condition of breathing air(T₀), breathing pure oxygen 5 minutes(T₁), after intubation(T₂)and mechanical ventilation five minutes(T₃). The grade of the exposure in operation field, the operative time, indwelling of gastric suction tube, the time of no ventilation in group R were recorded, too.

Compared to T₁ time point, PaO₂ and pH in group R decreased, but PaCO₂ was significantly higher at T₂ time point(P<0.05);PaO₂ and pH in group R were lower, but PaCO₂ was significantly higher than group C at T₂ time point(P<0.05).After 5 minutes mechanical ventilation,the PaCO₂ and pH in two groups were restored to the preoperative level(P>0.05),but SpO₂ and PaO₂ were higher than preoperative at every time point(P<0.05).The incidence of Indwelling gastric suction tube is higher in group C than in group R,the grade of exposure in the operation field were better in group R than in group C(P<0.05).

Application of rocuronium rapid sequence induction technique in laparoscopic cholecystectomy can improve the operative conditions and field, it can be safely used in clinical anesthesia.

Rocuronium; Anesthesia technique; Laparoscopic cholecystectomy