The reversal effect of abnormal savda munziq total flavonoids on leukemia cell lines
Hailiqiguli Nuriding, Wang Xuemei, Yan Mei
Published 2016-10-01
Cite as Chin J Prim Med Pharm, 2016,23(19): 2905-2910,C19-2
. DOI: 10.3760/cma.j.issn.1008-6706.2016.19.007
Abstract
ObjectiveTo investigate the reversal effect of abnormal savda munziq total flavonoids on leukemic cell lines.
MethodsCCK-8 method was used to detect the cytotoxicity of abnormal savda munziq total flavonoids on leukemia cells, by multivariate analysis of variance in the chemotherapy drug intervention, further calculated the reversal fold.
ResultsCCK-8 results showed that with the increase of concentration of ASMq800(μg/mL) compared with 200(μg/mL) and 400(μg/mL), the A value of K562/ADR cells gradually decreased, the growth curve suggested that with the increase of ASMq concentration in K562/ADR cell, survival time was shortened, the inhibition of the cells was significantly increased.Different concentrations of ASMq on the adriamycin toxicity with increase of concentration of adriamycin, the inhibition of ASMq on multidrug resistance cell line was significantly higher.The reversal multiples calculated that with the increase of ASMq concentration 600 μg/mL and 900 μg/mL, the reversal index increased significantly 2.485 times and 3.651 times.
ConclusionASMq on human leukemia multidrug resistance cell line K562/ADR could reverse the drug resistance, the reversal mechanism needs further study.
Key words:
Abnormal savda munziq total flavonoids; Leukemia; Multidrug resistance cell; Reversal
Contributor Information
Hailiqiguli Nuriding
Department of Peadiatrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
Wang Xuemei
Department of Peadiatrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
Yan Mei
Department of Peadiatrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China
