Original Article
Efficacy of montelukast sodium in the treatment of stable chronic obstructive pulmonary disease
Ni Nan, Lin Lin, Yang Shenjia, Xue Yunxin
Published 2017-10-01
Cite as Chin J Prim Med Pharm, 2017,24(19): 2885-2888. DOI: 10.3760/cma.j.issn.1008-6706.2017.19.002
Abstract
ObjectiveTo investigate the application value of montelukast in patients with stable chronic obstructive pulmonary disease (COPD).
Methods64 patients with stable COPD in Jinqiu Hospital of Liaoning Province from December 2015 to December 2016 were randomly divided into observation group and control group according to the digital table, 32 cases in each group.The two groups were given routine treatment, including cough, phlegm, oxygen therapy, smoking cessation, rehabilitation treatment, regular use of long-acting bronchodilators, on this basis, the observation group was treated with montelukast sodium.After 12 weeks of treatment, the patients were assessed for airway improvement and quality of life before and after treatment, and recorded the two groups of acute exacerbation and adverse drug reactions.
ResultsThe two groups had improved lung function and quality of life after treatment, but after treatment, the FEV1, FVC and FEV1 actual/FEV1 prediction of the observation group were significantly higher than those of the control group, the differences were statistically significant (t=2.49, 1.77, 1.85 all P<0.05). After treatment, the 6 minutes walking distance of the observation group was longer than that of the control group, Borg score of the observation group was lower than that of the control group, the differences were statistically significant (t=1.83, 6.66, all P<0.05). After treatment, the SGRQ score in the observation group was lower than that of the control group, the difference was statistically significant[(51.15±3.14)points vs.(54.83±4.03)points, t=3.94, P<0.01].
ConclusionMontelukast can effectively improve the stability of COPD pulmonary function and quality of life, and with high safety.
Key words:
Pulmonary disease, chronic obstructive; Montelukast sodium; Clinical observation
Contributor Information
Ni Nan
Department of Respiratory Medicine, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, China
Lin Lin
Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, China
Yang Shenjia
Department of Respiratory Medicine, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, China
Xue Yunxin
Department of Respiratory Medicine, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning 110016, China
