Original Article
Clinical value of tumor marker combined with cytokeratin 18 and 19 in the diagnosis of malignant tumors
Fengju Cheng, Zhihu Wang, Fengjiao Cheng, Yanchao Ma
Published 2018-03-15
Cite as Chin J Prim Med Pharm, 2018, 25(6): 763-766. DOI: 10.3760/cma.j.issn.1008-6706.2018.06.022
Abstract
ObjectiveTo investigate the clinical value of tumor marker combined with cytokeratin 18 and 19 in the diagnosis of malignant tumors.
Methods264 patients with malignant tumor were selected as the observation group.During the same period, 136 patients with benign tumor were selected as the control group.The tumor markers, cytokeratin 18 (CK18) and cytokeratin 19 (CK19) levels were compared between the two groups, and the positive detection rate of tumor markers combined with CK18 and CK19 were analyzed.
ResultsThe serum CK18 and CK19 levels of the observation group were (25.48±75.14) U/L, (18.67±64.85)U/L, respectively, which were significantly higher than those of the control group[(0.56±1.52)U/L, (0.76±0.43)U/L], the differences were statistically significant (t=17.38, 15.75, all P<0.05). The serum levels of CEA, CA125, CA50, CA19-9 and TSGF of the observation group were (21.24±30.16) μg/L, (69.85±112.75) mU/L, (47.32±121.81)mU/L, (41.87±20.65) mU/L, (91.64±43.84) mU/L, respectively, which were significantly higher than those of the control group [(1.27±0.85) ng/mL, (15.82±3.87) mU/L, (12.85±31.65) mU/L, (6.89±4.85) mU/L, (38.35±8.01) mU/L], the differences were statistically significant (t= 15.73, 16.89, 14.86, 17.79, 16.73, all P<0.05). The positive detection rates of CK18 and CK19 for gastric cancer (66.67%) and lung cancer (77.14%) were significantly higher than tumor markers, and the differences were statistically significant (χ2=5.67, 6.78, all P<0.05). The positive detection rate of tumor markers combined with CK18 and CK19 for malignant tumors (75.00%) was significantly higher than CK18 and CK19 joint detection (65.91%), tumor markers (46.97%), the differences were statistically significant (χ2=6.78, 7.12, all P<0.05).
ConclusionTumor markers combined with CK18 and CK19 detection is helpful to improve the detection rate of malignant tumors and provide effective basis for following treatment.
Key words:
Tumor markers, biological; Keratins; Neoplasms; Diagnosis
Contributor Information
Fengju Cheng
Department of Clinical Laboratory, the People's Hospital of Dongping County, Shandong 271500, China
Zhihu Wang
Department of Otorhinolaryngology, the People's Hospital of Dongping County, Shandong 271500, China
Fengjiao Cheng
Operation Room, Jieshan Health Center of Dongping County, Shandong 271500, China
Yanchao Ma
Food and Drug Inspection Brigade, Food and Drug Administration of Dongping County, Shandong 271500, China