Original Article
Clinical significanc of IL-1β, IL-8 and MMP-2/9 in patients with breast cancer
Xing Hanfei, Yan Hui, Ji Xiumeng, Song Shuling, Zhou Ning
Published 2018-03-15
Cite as Chin J Prim Med Pharm, 2018,25(6): 756-759. DOI: 10.3760/cma.j.issn.1008-6706.2018.06.020
Abstract
ObjectiveTo detect the interleukin-1β (IL-1β), interleukin-8 (IL-8) and matrix metalloproteinase-2/9 (MMP-2/9) levels in breast cancer patients, and to explore the relationship and clinical significance of IL-1β, IL-8 and MMP-2 / 9 with development of breast cancer.
MethodsThe serum samples of 60 cases with breast cancer(A group), 30 cases of breast hyperplasia(B group), 30 healthy subjects(C group), 60 breast cancer patients one month after operation(D group) were randomly collected.The serum levels of IL-1β, IL-8, MMP-2/9 in the four groups were detected.
ResultsCompared with C group[(35.93±3.44)ng/L, (17.63±2.73)ng/L, (91.55±2.43)ng/L, (99.71±3.94)ng/L], the IL-1β, IL-8, MMP-2, MMP-9 levels in A group[(154.75±4.45)ng/L, (62.88±3.16)ng/L, (213.04±2.51)ng/L, (253.04±2.51)ng/L] and D group[(104.75±3.78)ng/L, (39.94±3.16)ng/L, (148.26±2.31)ng/L, (153.04±2.51)ng/L] were significantly increased, the differences were statistically significant (A group: t=128.21, 66.90, 219.59, 224.38, all P<0.05; D group: all P<0.05). Compared with C group, the IL-1β, IL-8, MMP-2, MMP-9 levels of B group were not significantly increased [(56.22±2.94)ng/L, (20.63±2.36)ng/L, (104.75±3.16)ng/L, (109.71±3.94)ng/L] (t=24.56, 4.55, 5.38, 4.55, all P<0.05). Compared with A group, the IL-1β, IL-8, MMP-2, MMP-9 levels of D group were significantly reduced, the differences were statistically significant(t=66.33, 39.76, 147.14, 218.22, all P<0.05).
ConclusionThere is a close relationship between IL-1β, IL-8, MMP-2/9 and breast cancer development, combined detection of four indicators has important implication for clinical diagnosis and treatment of breast cancer.
Key words:
Interleukin-1beta; Interleukin-8; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Breast neoplasms
Contributor Information
Xing Hanfei
Department of Thyroid Breast Surgery, Binzhou Central Hospital, Binzhou, Shandong 251700, China
Yan Hui
Ji Xiumeng
Song Shuling
Zhou Ning