Effects of probiotics combined with oral scaling in the treatment of patients with chronic atrophic gastritis
Shi Damin, Chen Rong
Published 2018-05-15
Cite as Chin J Prim Med Pharm, 2018,25(10): 1267-1271. DOI: 10.3760/cma.j.issn.1008-6706.2018.10.012
Abstract
ObjectiveTo investigate the safety and effects of probiotics and oral scaling in the treatment of patients with chronic atrophic gastritis.
Methods180 patients with chronic atrophic gastritis were chosen as study objects.The patients were randomly divided into control group and research group according to the digital table, with 90 cases in each group.The control group received sequential therapy and oral scaling, the research group was given oral scaling combined with probiotics.After treatment for 3 months, the clinical effects, symptom score, pathology score, Hp clearing rate and adverse reaction between the two groups were compared.
ResultsThe total effective rate of the research group(92.22%) was higher than that of the control group(82.22%), the difference was statistically significant (χ2=4.038, P<0.05). The gastric Hp eradication rate of the research group(96.67%) was higher than that of the control group(86.67%), the difference was statistically significant (χ2=5.891, P<0.05). There was no statistically significant difference in positive rate of oral Hp between the two groups (P>0.05). Before treatment, the symptom score and pathology score between the two groups had no statistically significant differences(all P>0.05). After treatment, the symptom score and pathology score of the research group were (6.41±1.09)points, (5.46±0.94)points, respectively, which were significantly lower than those of the control group[(7.56±1.18)points, (8.12±1.04)points], the differences were statistically significant (t=8.026, 9.843, all P<0.05).7 cases(7.78%) of adverse reaction occurred in the research group, and 5 cases(5.56%) in the control group, the difference was not statistically significant between the two groups(χ2=0.357, P>0.05).
ConclusionProbiotics combined with oral scaling on the basis of sequential therapy in the treatment of patients with chronic atrophic gastritis can effectively improve the Hp clearing rate and clinical symptom, and with good effects and safety.
Key words:
Gastritis, atrophic; Helicobacter pylori; Oral health; Probiotics
Contributor Information
Shi Damin
Department of Gastroenterology, Laiyang Central Hospital of Yantai, Yantai, Shandong 265200, China
Chen Rong