Original Article
Clinical observation of Qingrehuatan method in the treatment of insomnia elderly patients with benzodiazepines dependence
Chen Jiahe, Wang Yuefeng, Yuan Song, Cao Shihong, Zhang Jiejing, Le Haifeng
Published 2018-07-15
Cite as Chin J Prim Med Pharm, 2018,25(14): 1833-1836. DOI: 10.3760/cma.j.issn.1008-6706.2018.14.016
Abstract
ObjectiveTo investigate the clinical curative effect of Qingrehuatan method in the treatment of insomnia elderly patients with benzodiazepines dependence.
MethodsFrom April 2016 to April 2017, 49 insomnia elderly patients with benzodiazepines dependence in the Second People's Hospital of Zhoushan were divided into the observation group(20 cases) and control group (29 cases) according to the different treatment methods.In the gradual reduction at the same time, the control group was treated with trazodone, the observation group was treated with Qingrehuatan method.Before treatment and after treatment for 1 course, the revised Pittsburgh sleep quality scale (PSQI), index of insomnia symptom score, TCM symptom score, Zung Anxiety Rating Scale score, Wechsler Adult Intelligence Scale(WAIS-RC) and Wechsler Memory Scale(WMS-RC) score were observed in the two groups.
ResultsAfter treatment, the rate of withdrawal and discontinuation of the observation group was significantly higher than that of the control group(90.0% vs.68.9%), the difference was statistically significant (χ2=6.918, P<0.05). After treatment, the PSQI scores and symptom scores of the two groups were significantly decreased, and the PSQI scores and TCM symptom scores of the observation group improved significantly better than those of the control group[(8.8±1.1)points vs.(10.6±1.3)points, (2.9±0.8)points vs.(4.6±1.2)points], the differences were statistically significant(t=5.063, 5.535, all P<0.05). After treatment, the Zung Anxiety Scale scores of the two groups were significantly lower, and the improvement of the observation group was significantly better than that of the control group[(42.90±5.65)points vs.(48.21±5.27) points], the difference was statistically significant(t=3.366, P<0.05). After treatment, the long-term memory, short-term memory and memory quotient of the two groups were significantly increased, and short-term memory and memory quotient of the observation group improved significantly better than those of the control group[(23.30±5.31)points vs.(20.55 ±6.58)points, (76.67±12.70)points vs.(67.36±19.13)points], the differences were statistically significant (t=2.274, 2.047, all P<0.05).
ConclusionQingrehuatan method in the treatment of insomnia elderly patients with benzodiazepines dependence can improve the possible reduction in the process of stopping drug withdrawal symptoms and memory function, and can improve the symptoms of patients at the same time, and it is worthy of clinical application.
Key words:
Sleep initiation and maintenance disorders; Benzodiazepines; Medicine, chinese traditional; Aged
Contributor Information
Chen Jiahe
Department of Psychiatry, the Second People's Hospital of Zhoushan, Zhoushan, Zhejiang 316000, China
Wang Yuefeng
Yuan Song
Cao Shihong
Zhang Jiejing
Le Haifeng
类药物依赖性失眠临床观察
类药物依赖性失眠的临床疗效。
类药物依赖性失眠患者根据治疗方法的不同分为观察组(20例)和对照组(29例)，在渐次减量的同时，对照组采用曲唑酮，观察组采用清热化痰法治疗。分别于用药前及1个疗程后观察修订匹兹堡睡眠质量量表(PSQI)指数失眠症状积分、中医症状积分、Zung氏焦虑评定量表积分、韦氏成人智力量表(WAIS-RC)和韦氏记忆量表(WMS-RC)积分。
依赖性失眠具有良好的疗效，在改善患者症状的同时，还可以改善减停药过程中可能出现的戒断症状，提高记忆功能，值得临床应用。
类药物是治疗失眠症的主要药物，其短期疗效可靠，但长期不合理的运用和滥用会产生药物依赖等副作用，在老年患者中尤为显著[
类药物依赖性失眠的临床疗效进行探讨，现报告如下。
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