Effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease in convalescent stage
Xueping Zhang, Ying Zhang, Xiaofen Ma, Xin Li, Zhencai Hu, Yunqing Zhai
Published 2019-11-01
Cite as Chin J Prim Med Pharm, 2019, 26(21): 2588-2592. DOI: 10.3760/cma.j.issn.1008-6706.2019.21.007
Abstract
ObjectiveTo study the effect of doxofylline on acute exacerbation of chronic obstructive pulmonary disease (COPD) and reduce the risk of early recurrence.
MethodsFrom January 2016 to January 2018, 164 patients with acute exacerbation of COPD in Binzhou Central Hospital were randomly divided into two groups by random digital table: control group (n=82) and observation group (n=82). The control group was given tiotropium bromide and budesonide/formoterol.The observation group was treated with oral doxophylline bid for 8 weeks on the basis of inhaled drugs.The recovery time, acute exacerbation rate, FEV1, CAT score and 6-minute walking test were compared between the two groups.
ResultsThe time of convalescent stage in the observation group was shorter than that in the control group[(16.89±5.15)d vs.(19.12±6.29)d, t=2.48, P=0.014], and the acute exacerbation rate of the observation group was lower than that of the control group (26.83% vs.41.46%, χ2=4.58, P=0.032). There was no statistically significant difference in FEV1[(45.59±9.82)% vs.(44.26±9.03)%, t=0.90, P=0.369], and the CAT score of the observation group was better than that of the control group [(19.32±6.16)points vs.(21.71±6.62)points, t=2.39, P=0.018]. The 6-minute walking distance of the observation group was longer than that of the control group[(146.32±10.20)m vs.(135.69±11.59)m, t=6.23, P=0.000], and the finger pulse oxygen of the observation group was higher than that of the control group[(94.12±5.09)% vs.(92.06±6.21)%, t=2.23, P=0.026]. The respiratory rate in the observation group was slower than that in the control group[(20.38±7.32)times/min vs.(22.86±6.53)times/min, t=2.29, P=0.023], and there was no statistically significant difference in heart rate[(98.24±12.35)bpm vs.(101.38±15.03)bpm, t=1.46, P=0.146]. No serious adverse drug reactions were found in both two groups.
ConclusionAs a beneficial supplement of inhaled drugs in convalescent COPD, doxofylline can shorten the recovery time, reduce the early acute exacerbation rate and improve the symptoms, which is worthy of clinical reference.
Key words:
Pulmonary disease, chronic obstructive; Forced expiratory volume; Doxofylline
Contributor Information
Xueping Zhang
Department of Respiratory Medicine, Binzhou Central Hospital, Binzhou, Shandong 251700, China
Ying Zhang
Xiaofen Ma
Xin Li
Zhencai Hu
Yunqing Zhai
