Original Article
Therapeutic effect of intravenous thrombolysis combined with drug therapy on mild ischemic stroke
Lou Gang, Chi Lifen, Chen Weili, Chai Zhenxiao, Xia Kai, Wu Chaowen
Published 2020-03-01
Cite as Chin J Prim Med Pharm, 2020,27(05): 563-567. DOI: 10.3760/cma.j.issn.1008-6706.2020.05.012
Abstract
ObjectiveTo explore the effect of dual antiplatelet combined with calf serum deproteinized injection in the treatment of mild ischemic stroke after intravenous thrombolysis.
MethodsFrom October 2017 to December 2018, 82 patients with mild ischemic stroke who were diagnosed in the People's Hospital of Ruian were selected.The patients were divided into control group (41 cases) and observation group (41 cases) according to random number table method.The control group was treated with aspirin after intravenous thrombolysis.On this basis, the observation group was treated with dual antiplatelet combined with calf serum deproteinized injection.The course of treatment was 3 months in both two groups.The total effective rate, the changes of hemorheological indicators, the improvement of neurological deficit, the ability of daily living and the ability of returning to society were compared between the two groups before and after treatment.The complications and prognosis were recorded.
ResultsThe total effective rate of the observation group was 95.12% (39/41), which was higher than 78.05% (32/41) of the control group (χ2=5.145, P<0.05). After treatment, the National Institutes of Health Stroke Score Scale (NIHSS) score, Modified Rankin Score (mRS), Barthel index (BI) score of the observation group were (0.34±0.18)points, (92.15±6.73)points, (0.87±0.36)points, respectively, which of the control group were (0.92±0.35)points, (76.05±4.86)points, (1.64±0.52)points, respectively, there were statistically significant differences between the two groups (t=8.592, 11.308, 7.099, all P<0.05). The whole blood viscosity, plasma viscosity and platelet aggregation rate of the observation group were (4.13±0.36)mPa/s, (1.39±0.31)mPa/s, (32.35±2.61)%, respectively, which were lower than those of the control group [(8.65±0.72)mPa/s, (1.62±0.47)mPa/s, (39.07±3.25)%] (t=32.740, 2.382, 9.400, all P<0.05). There were no cases of cerebral hemorrhage and death in the two groups, and there was no statistically significant difference in recurrence rate between the two groups (χ2=2.565, P>0.05).
ConclusionAfter intravenous thrombolytic therapy for patients with mild ischemic stroke, dual antiplatelet therapy combined with calf serum deproteinized injection can improve the neurological function, life ability and hemorheological indicators of patients, with good prognosis, it is safe and effective.
Key words:
Stroke; Thrombolytic therapy; Aspirin; Platelet aggregation inhibitors; Calf serum deproteinized injection; Drug therapy, combination; Hemorheology; Prognosis
Contributor Information
Lou Gang
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China
Chi Lifen
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China
Chen Weili
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China
Chai Zhenxiao
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China
Xia Kai
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China
Wu Chaowen
Department of Neurology, the People's Hospital of Ruian (the Third Affiliated Hospital of Wenzhou Medical University), Ruian, Zhejiang 325200, China