Dynamic research about the change of the behavior and hippocampal volume of rat depressive model
LUO Yi-feng, WANG Dong-qing, LI Yue-feng, SUN Wei-bin, HE Wei, YIN Rui-gen, XU Yun-fei, WANG Zheng-chao, ZHAO Liang
Published 2010-12-20
Cite as Chin J Behav Med & Brain Sci, 2010,19(12): 1102-1104. DOI: 10.3760/cma.j.issn.1674-6554.2010.12.017
Abstract
Objective To explore the dynamic change and correlation of the behavior and hippocampal volumes by MRI of rat depressive model. Methods Based on the evaluation of ethology, thirty SD rats were randomly and equally divided into control group and model group which was exposed to chronic unpredictable mild stress for 8 weeks. The body weight, fluid consumption test and Morris water maze test were done at the beginning and per week while the bilateral hippocampal volumes of every rat were measured by high field MRI at the beginning and per two weeks. Results Based on the behavioral data,the rat depressive model was established successfully,and changed dynamically. On 4th week,the left hippocampal volumes of depressive rat were significantly reduced (model group(37.13 ±2.40)mm3 ,control group (39.05 ±2.05)mm3, t=2.36, P<0.05) while the right ones did not. On 6th week, the right ones began to reduce significantly ( model group ( 37.85 ± 2.11 ) mm3, control group ( 39.44 ± 2.10 ) mm3, t = 2.07, P < 0.05 ) while the left one still reduced, but the extent of the left's reduction was bigger than the right( left:15% ,right:8% ). And there was apparent correlation between the behavior and the reduction of hippocampal volumes. Conclusion The behavior and hippocampal volumes of rat depressive model changes dynamically,and there was a regularity of them.
Key words:
Depressive model; Behavior; Magnetic resonance imaging; Hippocampus
Contributor Information
LUO Yi-feng
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
WANG Dong-qing
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
LI Yue-feng
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
SUN Wei-bin
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
HE Wei
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
YIN Rui-gen
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
XU Yun-fei
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
WANG Zheng-chao
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China
ZHAO Liang
Department of Medical Imaging, Clinical Medical of Jiangsu University, Zhenjiang 212001, China