Clinical Research
Association between serum IL-6 level and sustained attention in patients with major depressive disorder
Jie Chen, Li Hui, Baohua Zhang, Gang Ye, Hongliang Zhu, Zhen Tang, Jia Li, Wenjie Tang
Published 2018-02-20
Cite as Chin J Behav Med & Brain Sci, 2018, 27(2): 169-173. DOI: 10.3760/cma.j.issn.1674-6554.2018.02.014
Abstract
ObjectiveTo examine the correlation between serum interleukin-6 (IL-6) levels and sustained attention in patients with major depressive disorder (MDD).
Methods30 patients with MDD and 30 healthy controls were enrolled in the case-control study. Serum IL-6 levels in all subjects were assessed by sandwich enzyme-linked immunosorbent assay (ELISA). Sustained attention in all subjects was measured respectively using rapid visual information processing(RVP) task in the Cambridge neuropsychological tests automated battery (CANTAB).
ResultsSerum IL-6 levels in patients with MDD were significantly higher than those in healthy controls after controlling for gender, age, education, smoking, and BMI ((12.03±0.83) pg/ml , (2.77±0.24) pg/ml) (P<0.01). RVP total misses and RVP mean latency in patients with MDD were higher than those in healthy controls after controlling for gender, age, education, smoking, and BMI(RVP total misses (10.20±4.44), (5.37±3.67), P=0.008, RVP latency (486.78±135.47)ms, (370.58±72.42)ms, P=0.014). Serum IL-6 level were positively correlated with RVP mean latency in patients with MDD (r=0.46, P=0.011). But there were no correlation between serum IL-6 level and RVP total hits and RVP total misses in patients with MDD( P>0.05), and there were also no relationship between serum IL-6 levels and RVP task in healthy controls( P>0.05).
ConclusionsSerum IL-6 level may be implicated in the impairment of sustained attention in patients with MDD, and elevated IL-6 level may influence the susceptibility to MDD.
Key words:
Major depressive disorder; IL-6; Sustained attention; Association
Contributor Information
Jie Chen
First School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325000, China
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Li Hui
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Baohua Zhang
Department of Psychosomatic Medicine, Beijing Hui-long-guan Hospital, Peking University, Beijing 102200, China
Gang Ye
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Hongliang Zhu
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Zhen Tang
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Jia Li
Research Center of Biological Psychiatry, The Affiliated Guangji Hospital of Soochow University, Suzhou 215137, China
Wenjie Tang
First School of Clinical Medicine, Wenzhou Medical University, Wenzhou 325000, China
