Clinical Research
A magnetic resonance imaging study on brain surface morphology change in patients with first-episode obsessive compulsive disorder
Feng Juanjuan, Cheng Jingliang, Shang Xiaoping, Niu Qihui, Yang Lei, Li Youhui
Published 2018-04-20
Cite as Chin J Behav Med & Brain Sci, 2018,27(4): 338-342. DOI: 10.3760/cma.j.issn.1674-6554.2018.04.010
Abstract
ObjectiveTo analyze the brain structure changes of the first-episode obsessive compulsive disorder (OCD) patients who were scanned by three-dimensional structure magnetic resonance imaging.
MethodsAccording to the diagnostic criteria of OCD in American Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV), the fist-episode obsessive compulsive disorder patients as case group(OCD, n=26) and the adult healthy volunteers as control group (control group, n=25) were selected.All subjects were assessed with Yale-Brown obsessive-compulsive scale(Y-BOCS), Hamilton Anxiety rating Scale (HAMA) and Hamilton Depression Rating Scale(HAMD), and then, they received 3D-MRI scanning runs.All the data was processed with freesurfer software and analyzed about cerebral cortical volume, cortical thickness, cortical surface area, the local gyrification index and subcortical nuclei volume.
ResultsCompared with control group, the cerebral cortical thickness of OCD group increased at the left postcentral gyrus((2.223±0.118)mm), left supramarginal gyrus((2.486±0.027)mm) and left parahippocampal gyrus((2.399±0.164)mm). The cerebral cortical surface area larged at the right inferior frontal gyrus((1.036±0.079)mm2), right paracentral lobule((0.827±0.048)mm2)and medial orbitofrontal((0.990±0.083)mm2), and decreased at right superior parietal lobule((0.779±0.040)mm2), right inferior parietal lobule((0.767±0.093)mm2)and right inferior temporal gyrus((0.888±0.070)mm2). The cerebral cortical volume increased at the right inferior frontal gyrus((2.330±0.223)mm3). The cerebral cortical local gyrification index decreased at right middle temporal gyrus(2.893±0.288)and left inferior temporal gyrus(2.589±0.100).
ConclusionThe first-episode OCD patients have multiple changes of brain structures, and this changes were priority for the frontal lobes, orbital frontal, parietal lobe, temporal lobe and hippocampus.The changes in these regions maybe have close relationship with symptoms of OCD.
Key words:
First-episode obsessive-compulsive disorder; Magnetic resonance imaging; Freesurfer scanning images software; The local gyrification index
Contributor Information
Feng Juanjuan
Department of Rehabilatition, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Cheng Jingliang
Department of Magnetic resonance, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Shang Xiaoping
Department of Medical Records, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Niu Qihui
Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Yang Lei
Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Li Youhui
Department of Psychiatry, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
