Clinical Research
Study on functional connectivity between the subgenual anterior cingulate cortes and limbic cortices in predicting the efficacy of early antidepressant treatment outcome
Wang Qiang, Tian Shui, Tang Hao, Yan Rui, Shi Jiabo, Chen Yu, Lu Qing, Yao Zhijian
Published 2018-06-20
Cite as Chin J Behav Med & Brain Sci, 2018,27(6): 499-504. DOI: 10.3760/cma.j.issn.1674-6554.2018.06.004
Abstract
ObjectiveTo explore the role of functional connectivity(FC) between the subgenual anterior cingulate cortes(sgACC) and limbic cortices in predicting the efficacy of early antidepressant treatment.
MethodsResting state magnetoencephalography(MEG) data were collected from 32 patients with major depressive disorder(MDD) and 20 matched healthy control subjects at baseline.According to whether the HAMD17 total score reduction rate reached 50% after 2 weeks, the patients were divided into responder group and non-responder group.The difference of the FC, the relationship between the FC and the change rate of HAMD17 were explored.
ResultsCompared with controls, MDD patients showed decreased connectivity of the sgACC with the right hippocampus(MNI coordinate: x=30, y=-3, z=-24; F=5.11, P=0.028), the right amygdala(MNI coordinate: x=22, y=-2, z=-15; F=6.90, P=0.012) and the left amygdala(MNI coordinate: x=-24, y=-6, z=-16; F=5.75, P=0.020). Compared with non-responders, the connectivity of the sgACC with the right hippocampus(MNI coordinate: x=30, y=-3, z=-24; F=8.74, P=0.0065), the right amygdala(MNI coordinate: x=22, y=-2, z=-15; F=12.417, P=0.0016) were higher in responders.Pretreatment connectivity of the sgACC with the right hippocampus(r=-0.50, P=0.0066), the right amygdala(r=-0.56, P=0.0018) were negatively correlated with clinical improvement.ROC analyses confirmed the value of the connectivity of sgACC with the right hippocampus(area under curve(AUC)=0.71, P=0.042), the right amygdala(AUC=0.73, P=0.029) in classifying responders versus non-responders in 2 weeks of treatment.
ConclusionThe decreased FC of the sgACC with the right hippocampus and the right amygdala at baseline is associated with a better improvement, which can potentially serve as a treatment outcome biomarker in early curative effect of depression.
Key words:
Major depressive disorder; Theta wave; Curative effect; Magnetoencephalography; Functional connectivity
Contributor Information
Wang Qiang
Medical School of Nanjing University, Nanjing 210093, China;Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Tian Shui
School of Biological Science and Medical Engineering Southeast University, Nanjing 210096, China
Tang Hao
Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Yan Rui
Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Shi Jiabo
Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Chen Yu
Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
Lu Qing
School of Biological Science and Medical Engineering Southeast University, Nanjing 210096, China
Yao Zhijian
Medical School of Nanjing University, Nanjing 210093, China; Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China
