Clinical Research
Correlation of the serum decorin levels and the cognitive function in first-episode drug-native patients with schizophrenia
Yan Xuan, Song Chen, Huimei An, Zhiren Wang, Fude Yang, Shuping Tan, Guigang Yang, Xiangyang Zhang, Dongfeng Zhou, Yunlong Tan
Published 2018-08-20
Cite as Chin J Behav Med & Brain Sci, 2018, 27(8): 744-748. DOI: 10.3760/cma.j.issn.1674-6554.2018.08.014
Abstract
ObjectiveTo explore the role of decorin (DCN) on the pathogenesis of schizophrenia by analyzing the correlation between serum DCN levels and cognitive impairment in the first-episode drug-native (FEDN) patients with schizophrenia.
Methods30 FEDN patients with schizophrenia and 30 age and gender matched healthy volunteers (control group) were enrolled.The psychopathological symptoms were assessed by the PANSS and the cognitive function was assessed by the MATRICS Consensus Cognitive Battery (MCCB). The serum DCN levels were measured by using enzyme linked immunosorbent assay (ELISA). The difference of DCN levels between the two groups were compared and the correlations of serum DCN levels to age, sex, the score of the MCCB and PANSS were analyzed.
ResultsThe serum DCN levels were lower in patients with schizophrenia than those in control group ((1.56±0.96) ng/ml vs (3.35±1.71)ng/ml, P<0.01). The serum DCN levels were positively correlated with the positive symptom score (r=0.41, P=0.03). The serum DCN levels were significantly negatively correlated with MCCB verbal fluency (r=-0.40, P=0.04), verbal memory (r=-0.42, P=0.02), visual memory (r=-0.39, P=0.04), continuous operation (r=-0.41, P=0.03), encoding symbols (r=-0.49, P=0.01), T line (r=-0.42, P=0.02) and total score (r=-0.55, P<0.01), and after controlling the age and gender, the relationships were still exist.
ConclusionIt suggests that serum DCN levels are associated with cognitive function in first-episode patients with schizophrenia, and that DCN may be involved in the pathogenesis of schizophrenia.
Key words:
Schizophrenia; Decorin; Cognitive impairments
Contributor Information
Yan Xuan
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Song Chen
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Huimei An
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Zhiren Wang
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Fude Yang
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Shuping Tan
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Guigang Yang
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Xiangyang Zhang
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
Dongfeng Zhou
Psychiatry Department, Peking University Sixth Hospital(Institute of Mental Health), Beijing 100191, China
Yunlong Tan
Psychiatry Department, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing 100096, China
