Clinical Research
Primary comparative study on the functional properties of cerebral resting state networks in neonates with hypoxic ischemic encephalopathy
Hongxin Li, Min Yu, Aibin Zheng, Kaihua Jiang, Qian Wang, Lichi Zhang, Wenjuan Tu, Peng Xue
Published 2018-09-20
Cite as Chin J Behav Med & Brain Sci, 2018, 27(9): 814-819. DOI: 10.3760/cma.j.issn.1674-6554.2018.09.009
Abstract
ObjectiveTo explore the functional properties of the brain’s resting state networks in neonates with hypoxic ischemic encephalopathy.
MethodsUse the methods of functional MRI probabilistic tractography and graph theory to compare the global and local functional properties of the brain’s resting state network between 12 cases of children with mild HIE and 14 cases of children with moderate/severe HIE.
ResultsIn terms of global topological properties, both the mild and moderate/severe group showed small-world properties.The γ and λ in the mild group were 2.450±1.642 and 1.542±0.564 and in the moderate/severe group were 2.331±1.554 and 1.353±0.672, respectively, which were in line with the characteristics of small-world properties (γ>1 and λ≈1). As far as local topological properties were concerned, the distribution of hub regions in the functional networks had smaller number of nodes in the moderate/severe group (8 nodes) than the mild group (14 nodes). The comparison of nodal efficiencies showed that the moderate/severe group had significantly reduced nodal efficiency in the left insula opercula, left supramarginal gyrus, left and right temporal pole and right middle temporal gyrus(the nodal efficiencies of the moderate/severe group: 0.4089±0.0865, 0.3377±0.1223, 0.3842±0.0898, 0.3508±0.1295, 0.3564±0.0843; the nodal efficiencies of the mild group : 0.4801±0.0762, 0.4465±0.0898, 0.4655±0.0812, 0.4640±0.0690, 0.4271±0.0636, all P<0.05).
ConclusionThe topological structure of resting state functional network in children with moderate and severe hypoxic-ischemic encephalopathy is obviously backward than that in children with mild hypoxic-ischemic encephalopathy, which may be related to abnormal language, movement and cognitive function in the late stage.
Key words:
Neonate; Hypoxic-ischemic encephalopathy; Resting-state functional magnetic resonance imaging; Brain networks; Small-world organization
Contributor Information
Hongxin Li
Neonatology Department, the Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou 213003, China
Min Yu
Medical School of Nantong University, Nantong 226000, China
Aibin Zheng
Neonatology Department, the Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou 213003, China
Kaihua Jiang
Children Health Research Center, the Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou 213003, China
Qian Wang
Biomedical Imaging Research Center, Shanghai Jiaotong University, Shanghai 200240, China
Lichi Zhang
Biomedical Imaging Research Center, Shanghai Jiaotong University, Shanghai 200240, China
Wenjuan Tu
Neonatology Department, the Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou 213003, China
Peng Xue
Children Health Research Center, the Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou 213003, China
